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Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways

ABSTRACT: Here we interrogated the in vitro metabolic effects of 189 drugs (including 169 of the drug-like compounds from the Malaria Box) using ultra-high performance liquid chromatography mass-spectrometry (UHPLC-MS). The resulting metabolic fingerprints provide information on the parasite biochemical pathways affected by pharmacologic intervention and offer a critical blueprint for selecting and advancing lead compounds as next-generation antimalarial drugs. Our results reveal several major classes of metabolic disruption, which allow us to predict the mode-of-action (MoA) for many of the Malaria Box compounds.

ORGANISM(S): Plasmodium Falciparum

TISSUE(S): Plasmodium Cells

DISEASE(S): Malaria

SUBMITTER: Manuel Llinás

PROVIDER: ST000441 | MetabolomicsWorkbench | Mon Jul 11 00:00:00 BST 2016

REPOSITORIES: MetabolomicsWorkbench

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