Mechanisms for Insulin Resistance in Polycystic Ovary Syndrome with metformin therapy: aminoadipic acid, lysine concentrations, and enrichment (part I)
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ABSTRACT: To determine whether altered lysine and α-aminoadipic acid (AAA) kinetics explain previous observations of increased lysine and AAA concentrations in PCOS compared to controls, as measured by baseline lysine and AAA flux in PCOS versus healthy controls using [α-15N]-lysine and [13C]-AAA stable isotope tracers as well as by comparing the conversion of [α-15N]-lysine to [15N]-AAA. To evaluate how hyperinsulinemia affects lysine and AAA kinetics. Changes in lysine and AAA flux during a hyperinsulinemic-euglycemic clamp will be evaluated in healthy controls and compared to the baseline changes in lysine and AAA flux in PCOS. PCOS cases at baseline and after 3 months of metformin therapy.
ORGANISM(S): Human Homo Sapiens
TISSUE(S): Blood
DISEASE(S): Polycystic Ovary Syndrome
SUBMITTER: Al Chang
PROVIDER: ST000947 | MetabolomicsWorkbench | Mon Apr 09 00:00:00 BST 2018
REPOSITORIES: MetabolomicsWorkbench
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