Development of a weaned pig model of enterotoxigenic E.coli-induced environmental enteropathy
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ABSTRACT: Environmental Enteropathy (EE) is a subclinical condition primarily effecting developing countries believed to be caused by chronic fecal-oral contamination. The condition is characterized by chronic gut inflammation, malabsorption, stunting of growth, stunted villi, and reduced efficacy of oral vaccines. Due to the similarity of the gastrointestinal tract and immune response of swine and humans, the piglet is an attractive model for studying this condition. In this present study, piglets were challenged with either a chronic or acute dose of pathogenic E.coli in an attempt to mimic the symptoms of EE over a 7 day trial period. Throughout the study a number of biological samples were collected for analysis and are presented here, including feces for untargeted metabolomics analysis.
ORGANISM(S): Sus Scrofa Pig
TISSUE(S): Feces
SUBMITTER: 
Justin Boeckman
PROVIDER: ST001041 | MetabolomicsWorkbench | Tue Aug 21 00:00:00 BST 2018
REPOSITORIES: MetabolomicsWorkbench
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