Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia coli
SUBMITTER: WEI LIU
PROVIDER: E-GEOD-43408 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Antimicrobial agents and chemotherapy 20130715 10
Antimicrobial peptides (AMPs) can cause lysis of target bacteria by directly inserting themselves into the lipid bilayer. This killing mechanism confounds the identification of the intracellular targets of AMPs. To circumvent this, we used a shuttle vector containing the inducible expression of a human cathelicidin-related AMP, LL-37, to examine its effect on Escherichia coli TOP10 under aerobic and anaerobic growth conditions. Induction of LL-37 caused growth inhibition and alteration in cell m ...[more]