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Metabolomic analysis of skeletal muscle in young and aged mice

ABSTRACT: Sarcopenia is the age-induced, progressive loss of skeletal muscle mass and function, which results in poor muscle performance. To better understand changes in skeletal muscles during sarcopenia, we performed a metabolomic analysis of skeletal muscle in young (8-week-old) and aged (28-month-old) mice using CE-TOFMS. Our data shows that the metabolites including glucose and polyamine metabolism were decreased in aged mice compared with young mice. In addition, neurotransmitter levels were higher in aged mice.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Muscle

DISEASE(S): Sarcopenia

SUBMITTER: Yasutomi Kamei

PROVIDER: ST001179 | MetabolomicsWorkbench | Mon May 06 00:00:00 BST 2019

REPOSITORIES: MetabolomicsWorkbench

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