Metabolomics

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Peroxide antimalarial treatment of K13-mutant and -wildtype P. falciparum parasites


ABSTRACT: Red blood cells (RBCs) infected with trophozoite stage P. falciparum parasites (Cam3.IIR539T or Cam3.IIrev lines) at 4% parasitaemia and 2% haematocrit were treated with 100 nM of DHA, OZ277 or OZ439 for a duration of 1, 3 and 5 h, respectively. The K13-mutant artemisinin resistant parasite line used was Cam3.IIR539T. The K13-wildtype artemisinin sensitive parasite line used was Cam3.IIrev. The Samples treated with vehicle (DMSO) acted as the untreated control.

ORGANISM(S): Human Homo Sapiens Plasmodium Falciparum Plasmodium Falciparum;homo Sapiens

TISSUE(S): Cultured Cells

DISEASE(S): Malaria

SUBMITTER: Carlo Giannangelo  

PROVIDER: ST001205 | MetabolomicsWorkbench | Wed Jun 26 00:00:00 BST 2019

REPOSITORIES: MetabolomicsWorkbench

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