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Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

ABSTRACT: We investigated potential metabolic mechanisms using untargeted liquid chromatography-mass spectrometry-based metabolomics on 577 plasma samples collected at age 6 months in the offspring of mothers participating in the n-3 LCPUFA randomized controlled trial. First, associations between the n-3 LCPUFA supplementation groups and child metabolite levels were investigated using univariate regression models and data-driven partial least square discriminant analyses (PLS-DA). Second, we analyzed the association between the n-3 LCPUFA metabolomic profile and asthma development using Cox-regression. Third, we conducted mediation analyses to investigate whether the protective effect of n-3 LCPUFA on asthma was mediated via the metabolome

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

SUBMITTER: Daniela Rago

PROVIDER: ST001212 | MetabolomicsWorkbench | Wed Jul 10 00:00:00 BST 2019

REPOSITORIES: MetabolomicsWorkbench

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Fish-oil supplementation in pregnancy, child metabolomics and asthma risk

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