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TGF-Beta 3 heterozygous mice

ABSTRACT: Transforming growth factor β (TGFβ) family comprises the main player in the development of fibrosis including three isoforms: TGFβ1, TGFβ2 and TGFβ3. TGFβ3 may play an antifibrotic role at the renal level, counteracting the role of TGFβ1, using a mouse model heterozygous for the TGFβ3 gene (TGFβ3+/-). Partial deletion of TGFβ3 causes in the mice albuminuria, loss of glomerular filtration rate, accelerated fibrosis, epithelial-to-mesenchymal transition and increment of glomerular basement membrane thickening.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Kidney

SUBMITTER: Borja Lanzon

PROVIDER: ST001303 | MetabolomicsWorkbench | Thu Dec 19 00:00:00 GMT 2019

REPOSITORIES: MetabolomicsWorkbench

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