Transcription profiling of thymotyctes from parp-2 -/- mice to determine whether dis-regulation of a genetic pathway could explain the increased apoptosis of these cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Enrique Aguado
PROVIDER: E-MEXP-755 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.
Yélamos José J Monreal Yolanda Y Saenz Luis L Aguado Enrique E Schreiber Valérie V Mota Rubén R Fuente Teodomiro T Minguela Alfredo A Parrilla Pascual P de Murcia Gilbert G Almarza Elena E Aparicio Pedro P Ménissier-de Murcia Josiane J
The EMBO journal 20060831 18
Poly-(ADP-ribose) polymerase-2 (PARP-2) belongs to a large family of enzymes that synthesize and transfer ADP-ribose polymers to acceptor proteins, modifying their functional properties. PARP-2-deficient (Parp-2-/-) cells, similar to Parp-1-/- cells, are sensitive to both ionizing radiation and alkylating agents. Here we show that inactivation of mouse Parp-2, but not Parp-1, produced a two-fold reduction in CD4+CD8+ double-positive (DP) thymocytes associated with decreased DP cell survival. Mic ...[more]
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