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A Metabolomic Signature of Glucagon Action in Healthy Individuals with Overweight/Obesity Humans

ABSTRACT: Objective: We sought to identify the circulating metabolites that would serve as markers of glucagon action. Design: In this study, we performed a continuous 72-hour glucagon infusion in healthy individuals with overweight/obesity. Participants were randomized to either glucagon (12.5 ng/kg/min) (GCG 12.5) or glucagon (25 ng/kg/min) GCG 25 or a placebo control were included. A comprehensive metabolomics analysis was then performed from plasma isolated at several time points during the infusion to identify markers of glucagon activity.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

DISEASE(S): Obesity

SUBMITTER: Katie Whytock

PROVIDER: ST001515 | MetabolomicsWorkbench | Mon Oct 26 00:00:00 GMT 2020

REPOSITORIES: MetabolomicsWorkbench

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