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Deletion of the diabetes candidate gene Slc16a13 in mice

ABSTRACT: The metabolome of plasma and liver lysates of Slc16a13 knockout mice was analyzed. Genome-wide association studies identified SLC16A13 as novel target gene in type 2 diabetes. The SLC16A13 gene encodes for SLC16A13/MCT13, a member of the solute carrier 16 family of monocarboxylate transporters. So far, biology and physiological function of SLC16A13 is unknown. Deletion of Slc16a13 is hypothezised to affect intrahepatocellular monocarboxylate availability, that drives increased oxidative phosphorylation, while reducing hepatic lipid content, thereby attenuating hepatic insulin resistance.

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Liver

DISEASE(S): Diabetes

SUBMITTER: Andreas Birkenfeld

PROVIDER: ST001643 | MetabolomicsWorkbench | Wed Jan 06 00:00:00 GMT 2021

REPOSITORIES: MetabolomicsWorkbench

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