Associations between the gut microbiome and metabolome in early life
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ABSTRACT: The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the taxonomic composition of the microbiome and its metabolic phenotype is undefined and complicated by redundancies in the taxon-function relationship within microbial communities. To inform a more mechanistic understanding of the relationship between the microbiome and health, we performed an integrative statistical and machine learning-based analysis of microbe taxonomic structure and metabolic function (using untargeted (binned) NMR and relative concentration data) in order to characterize the taxa-function relationship in early life.
ORGANISM(S): Human Homo Sapiens
TISSUE(S): Feces
SUBMITTER: Susan Sumner
PROVIDER: ST001813 | MetabolomicsWorkbench | Wed May 26 00:00:00 BST 2021
REPOSITORIES: MetabolomicsWorkbench
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