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Lipidomic characterization of Candida albicans in response to Aureobasidin treatment in vitro.

ABSTRACT: Candida albicans is an opportunistic yeast pathogen that causes a wide range of infections especially amongst immunocompromised patients. Aureobasidin A (AbA) has been shown to inhibit inositolphosphoryl ceramide synthase (IPCS), a key enzyme responsible for sphingolipid biosynthesis. There are limited studies exploring IPCS as a target molecule for antifungal treatment. It is hypothesized that the mechanism of AbA inhibition involves alteration of C. albicans phospholipid and sphingolipid profiles. The profiling of C. albicans phospholipid and sphingolipid upon exposure to 0.5-4 µg/ml of AbA were determined using Liquid chromatography-mass spectrometry (LC-MS).

ORGANISM(S): Candida Albicans

TISSUE(S): Yeast Cells

SUBMITTER: Nur Wahida Hamdan

PROVIDER: ST001982 | MetabolomicsWorkbench | Thu Sep 16 00:00:00 BST 2021

REPOSITORIES: MetabolomicsWorkbench

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