Transcriptomic and lipidomic analysis unravels the response of Faecalibacterium prausnitzii to calcium palmitate
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ABSTRACT: Infant formula is a suggested alternative to human milk if breastfeeding is not an option; vegetable oil blends are commonly used in infant formula (IF) to replace dairy fat, which can induce the formation of the poorly soluble soap calcium palmitate (CP) in the infant’s gut. Previously, we observed that CP at a low concentration of 0.01 mg/ml inhibits the growth of dominant infant bacteria such as Faecalibacterium prausnitzii both during the exponential phase as well as in the stationary phase. Here, we investigate the underlying mechanism of the CP inhibition on infant-gut bacteria using F. prausnitzii as a model by analysing its growth at a transcriptomic and lipidomic level.
ORGANISM(S): Faecalibacterium Prausnitzii
TISSUE(S): Bacterial Cells
SUBMITTER: Péter Horvatovich
PROVIDER: ST001987 | MetabolomicsWorkbench | Fri Nov 12 00:00:00 GMT 2021
REPOSITORIES: MetabolomicsWorkbench
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