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A targeted metabolomics study for assessing rodent thyroid toxicity

ABSTRACT: The thyroid gland regulates various physiological mechanisms in mammals/humans, such as individual development, cell proliferation and differentiation. Thus, disorders can lead to diseases. In this study, we aimed to apply targeted metabolomics approach to investigate rodent thyroid toxicity. For this purpose, male Wistar rats have been exposed to a direct (6-propyl-2-thiouracil, PTU) and an indirect (phenytoin) thyroid toxicant, respectively. Thereby, two doses (low:5ppm for PTU and 300ppm for phenytoin , high: 50ppm for PTU and 2400ppm for phenytoin) and three exposure time phase (short: 2 weeks, long:4 weeks, and long+recovery: 4weeks+2weeks) were investigated, allowing insights into the modes of action during thyroid toxicity. Targeted metabolomics were applied to both liver and thyroid gland tissue.

ORGANISM(S): Rat Rattus Norvegicus

TISSUE(S): Liver, Thyroid

DISEASE(S): Thyroid Toxicity

SUBMITTER: Zhipeng Wang

PROVIDER: ST002023 | MetabolomicsWorkbench | Mon Dec 20 00:00:00 GMT 2021

REPOSITORIES: MetabolomicsWorkbench

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