Metabolic impact of anticancer drugs Pd2Spermine and Cisplatin on the nonpolar extracts of brain from healthy mice (part 2)
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ABSTRACT: Platinum (Pt(II)) drugs, e.g. cisplatin (cDDP), are some of the most used chemotherapeutic agents, yet tumor acquired resistance and high toxicity are still current drawbacks. Palladium (Pd(II))-complexes are alternatives due to similar metal coordination and promising cytotoxic properties. Metabolomics can measure the metabolic response of drug-exposed tissues, unveiling insight into drug mechanisms and new markers of drug efficacy/toxicity. The present 1H NMR metabolomics study aims to characterize the in vivo response of the impact of a Pd(II)-complex with polyamine spermine (Pd2Spm), compared to cDDP, on nonpolar metabolism of brain from healthy mice at 1, 12 and 48 h post-injection times.
ORGANISM(S): Mouse Mus Musculus
TISSUE(S): Brain
DISEASE(S): Cancer
SUBMITTER: Tatiana João Carneiro
PROVIDER: ST002065 | MetabolomicsWorkbench | Mon Jan 10 00:00:00 GMT 2022
REPOSITORIES: MetabolomicsWorkbench
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