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Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients

ABSTRACT: 1H NMR spectra of EDTA-plasma from 246 COVID-19-positive subjects in the acute phase of infection were compared to those of 94 COVID-19-recovered subjects. The two cohorts are largely different (discrimination accuracy > 93%) due to a pool of 16 metabolites and 74 lipoprotein parameters significantly up- or down-regulated in the patients and within the healthy range in the recovered subjects. In 28 post-acute COVID-19-positive patients, the metabolites levels are reverted back to normality whereas the lipoprotein parameters are still altered. Therefore, the metabolite biomarkers might be used as the timeliest sign of the individual response to treatment or spontaneous healing.

ORGANISM(S): Human Homo Sapiens

TISSUE(S): Blood

DISEASE(S): Covid-19

SUBMITTER: Veronica Ghini

PROVIDER: ST002087 | MetabolomicsWorkbench | Thu Feb 17 00:00:00 GMT 2022

REPOSITORIES: MetabolomicsWorkbench

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