Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human immunodeficiency virus 1

ABSTRACT: HIV-1 quasispecies analysis

PROVIDER: PRJDB3502 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	DRR030218_1.fastq.gz	Fastqsanger.gz
	DRR030218_2.fastq.gz	Fastqsanger.gz
	DRR030219_1.fastq.gz	Fastqsanger.gz
	DRR030219_2.fastq.gz	Fastqsanger.gz
	DRR030220_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 200

Similar Datasets

Simian-Human immunodeficiency virus

Project description:Identification of drug- resistance mutations in majority and minority subpopulations of HIV-1 quasispecies

| PRJNA355237 | ENA

Human immunodeficiency virus 1

Project description:HIV WGS and Population Diversity Analysis

| PRJNA196138 | ENA

Human immunodeficiency virus

Project description:Comparison of HIV-1 and HIV-2 Mutagenesis by Illumina Sequencing

| PRJNA287455 | ENA

Human immunodeficiency virus 1

Project description:Broad neutralizing HIV antibodies

| PRJNA294363 | ENA

Human immunodeficiency virus 1

Project description:HIV LTR terminus sequence

| PRJDB9357 | ENA

Human immunodeficiency virus 1

Project description:Polymorphisms of HIV-1 integrase

| PRJDB3501 | ENA

Human immunodeficiency virus 1

Project description:Full-length HIV-1 envelope sequences

| PRJNA320111 | ENA

Human immunodeficiency virus 1

Project description:HIV-1 tropism determination Using NGS

| PRJDB3249 | ENA

Human immunodeficiency virus 1

Project description:Analysis for the regulation of transcriptional elongation of HIV-1 transcript by proviral non-coding RNA

| PRJDB1862 | ENA

Schlafen 5 Suppresses Human Immunodeficiency Virus Type 1 Transcription by Commandeering Cellular Epigenetic Machinery

Project description:Schlafen-5 (SLFN5) is an interferon-induced protein of the Schlafen family which are involved in immune responses and oncogenesis. To date, little is known regarding its anti-HIV-1 function. Here, the authors report that overexpression of SLFN5 inhibits HIV-1 replication and reduces viral mRNA levels, whereas depletion of endogenous SLFN5 promotes HIV-1 replication. Moreover, they show that SLFN5 markedly decreases the transcriptional activity of HIV-1 long terminal repeat (LTR) via binding to two sequences in the U5-R region, which consequently represses the recruitment of RNA polymerase Ⅱ to the transcription initiation site. Mutagenesis studies show the importance of nuclear localization and the N-terminal 1-570 amino acids fragment in the inhibition of HIV-1. Further mechanistic studies demonstrate that SLFN5 interacts with components of the PRC2 complex, G9a and Histone H3, thereby promoting H3K27me2 and H3K27me3 modification leading to silencing HIV-1 transcription. In concert with this, they find that SLFN5 blocks the activation of latent HIV-1. Altogether, their findings demonstrate that SLFN5 is a transcriptional repressor of HIV-1 through epigenetic modulation and a potential determinant of HIV-1 latency.

2022-05-24 | GSE197700 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data