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Malassezia sympodialis genomes (strain ATCC 42132 and four clinical isolates)

ABSTRACT: Genome sequencing and integrative gene annotation of Malassezia sympodialis

PROVIDER: PRJEB13283 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	GCA_900149135.1_sequence_report.txt	Txt
	GCA_900149145.1_sequence_report.txt	Txt
	GCA_900149155.1_sequence_report.txt	Txt
	GCA_900149165.1_sequence_report.txt	Txt

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Integrative genome annotation of Malassezia sympodialis

Project description:The skin commensal yeast Malassezia is associated with several skin disorders. To establish a reference resource, we sought to determine the complete genome sequence of Malassezia sympodialis and identify its protein-coding genes. A novel genome annotation workflow combining RNA sequencing, proteomics, and manual curation was developed to determine gene structures with high accuracy.

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Project description:This data set is part of a study where the genome of Malassezia sympodialis (strain ATCC 42132) was sequenced using long-read technology and annotated using RNA-seq and proteogenomics. RNA was extracted at two different culture times (2 and 4 days). Seven RNA-seq libraries were prepared from independent samples. Two samples (P2 and P3) were enriched for protein-coding RNA using poly(A)-selection. The remaining five samples were processed with RiboMinus to deplete ribosomal RNA, and thus retain both mRNA and non-ribosomal noncoding RNA for sequencing. In total, we obtained 71 million RNA-seq read pairs mapping to genomic regions other than the highly expressed ribosomal loci.

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