Proteomics

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Integrative genome annotation of Malassezia sympodialis

ABSTRACT: The skin commensal yeast Malassezia is associated with several skin disorders. To establish a reference resource, we sought to determine the complete genome sequence of Malassezia sympodialis and identify its protein-coding genes. A novel genome annotation workflow combining RNA sequencing, proteomics, and manual curation was developed to determine gene structures with high accuracy.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Malassezia Sympodialis (strain Atcc 42132) (atopic Eczema-associated Yeast)

DISEASE(S): Atopic Dermatitis

SUBMITTER: Yafeng Zhu  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD003773 | Pride | 2016-12-20

REPOSITORIES: Pride

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Dataset's files

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Action DRS
Malassezia_no_label_mix_2n15_days_200ug_IPG3-10_6RF_junction_bovine.msf Msf
Malassezia_no_label_mix_2n15_days_200ug_IPG3-10_Fr_01.raw Raw
Malassezia_no_label_mix_2n15_days_200ug_IPG3-10_Fr_02.raw Raw
Malassezia_no_label_mix_2n15_days_200ug_IPG3-10_Fr_03.raw Raw
Malassezia_no_label_mix_2n15_days_200ug_IPG3-10_Fr_04.raw Raw
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Publications

Complete and accurate genome assembly and annotation is a crucial foundation for comparative and functional genomics. Despite this, few complete eukaryotic genomes are available, and genome annotation remains a major challenge. Here, we present a complete genome assembly of the skin commensal yeast Malassezia sympodialis and demonstrate how proteogenomics can substantially improve gene annotation. Through long-read DNA sequencing, we obtained a gap-free genome assembly for M. sympodialis (ATCC 4  ...[more]

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