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Aspergillus tubingensis Whole Genome Sequencing

ABSTRACT: Whole-genome sequencing of Aspergillus tubingensis and overview of its secondary metabolism potential

PROVIDER: PRJEB19357 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	FUKH01.dat.gz	Other
	FUKH01.fasta.gz	Fasta.gz
	FUKH01.master.dat	Other
	ERR1823584_1.fastq.gz	Fastqsanger.gz
	ERR1823584_2.fastq.gz	Fastqsanger.gz

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Aspergillus tubingensis

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Aspergillus tubingensis CBS 134.48

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Project description:Aspergillus tubingensis CBS 134.48 Genome sequencing and assembly

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Aspergillus tubingensis strain:WU-2223L

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Project description:Aspergillus tubingensis strain:C2-2 Genome sequencing and assembly

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Expression analysis of Aspergillus nidulans OE::rsmA

Project description:Investigation of whole genome gene expression level changes in Aspergillus nidulans OE::rsmA compared to wild-type RDIT9.32 (veA). A twelve array study using total RNA recovered from six separate cultures of Aspergillus nidulans wild-type RDIT9.32 (veA) and six separate cultures of Aspergillus nidulans overexpressing rsmA (restorer of secondary metabolism A), using custom-designed, four-plex arrays. The experiment was divided into two runs. In the first run, three biological replicates each of Aspergillus nidulans wild-type RDIT9.32 (veA) and Aspergillus nidulans carrying a plasmid overexpressing rsmA under the control of the gpdA promoter were assayed. In the second run, three biological replicates each of Aspergillus nidulans wild-type RDIT9.32 (veA) and Aspergillus nidulans overexpressing rsmA at the native locus under the control of the gpdA promoter were assayed.

2012-01-17 | E-GEOD-34220 | biostudies-arrayexpress

Whole-genome sequencing of Aspergillus tubingensis G131 and overview of its secondary metabolism potential.

Project description:BACKGROUND:Black Aspergilli represent one of the most important fungal resources of primary and secondary metabolites for biotechnological industry. Having several black Aspergilli sequenced genomes should allow targeting the production of certain metabolites with bioactive properties. RESULTS:In this study, we report the draft genome of a black Aspergilli, A. tubingensis G131, isolated from a French Mediterranean vineyard. This 35 Mb genome includes 10,994 predicted genes. A genomic-based discovery identifies 80 secondary metabolites biosynthetic gene clusters. Genomic sequences of these clusters were blasted on 3 chosen black Aspergilli genomes: A. tubingensis CBS 134.48, A. niger CBS 513.88 and A. kawachii IFO 4308. This comparison highlights different levels of clusters conservation between the four strains. It also allows identifying seven unique clusters in A. tubingensis G131. Moreover, the putative secondary metabolites clusters for asperazine and naphtho-gamma-pyrones production were proposed based on this genomic analysis. Key biosynthetic genes required for the production of 2 mycotoxins, ochratoxin A and fumonisin, are absent from this draft genome. Even if intergenic sequences of these mycotoxins biosynthetic pathways are present, this could not lead to the production of those mycotoxins by A. tubingensis G131. CONCLUSIONS:Functional and bioinformatics analyses of A. tubingensis G131 genome highlight its potential for metabolites production in particular for TAN-1612, asperazine and naphtho-gamma-pyrones presenting antioxidant, anticancer or antibiotic properties.

| S-EPMC6389250 | biostudies-literature

Expression analysis of Aspergillus nidulans AN1599 (PbcR) overexpression mutant

Project description:Investigation of whole genome gene expression level changes in Aspergillus nidulans AN1599 (PbcR) overexpression mutant, compared to the FGSC A4 wild-type strain. Overexpression of the Zn(II)2Cys6 –type transcription factor, AN1599.4 (PbcR, pimaradiene biosynthetic cluster regulator), activates a secondary metabolite gene cluster in Aspergillus nidulans. Activation of the pathway in Aspergillus nidulans lead to a production of ent-pimara-8(14),15-diene.

2012-04-16 | GSE32954 | GEO

GNPS - Dyrehaven Streptomyces P9-A2 monoculture and coculture data with Aspergillus tubingensis

Project description:Extracts of Streptomyces sp. P9-A2 from Jaegersborg Dyrehaven, Denmark. Agar plug extracts from the inhibition zone of P9-A2 and Aspergillus tubingensis.

2023-11-06 | MSV000093305 | GNPS

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