Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Changes in gut microbiome under nutritional therapies

ABSTRACT: Examining changes in the gut microbiome of Crohn's Disease patients using two different nutritional therapies.

PROVIDER: PRJEB25264 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

DNA methylation in the arcuate nucleus of heifers under two nutritional schedules

Project description:DNA methylation was assessed in genomic DNA obtained from the arcuate nucleus of heifers fed to gain body weight at high (HG, n = 4) and low (LG, n = 4) rates from 4.5 to 8.5 mo of age. A methyl-CpG binding domain-based (MBD) protein assay was performed to capture fragments of methylated DNA (methylated-enriched DNA). Input (total) and methylated-enriched DNA were labeled with two different dyes and co-hybridized to a custom-designed oligonucleotide array targeted to genes associated with nutritional inputs and the control of puberty. The ratio of the log2 (enriched/input) of the normalized intensities, were determined. Data was analyzed comparing values of HG versus LG heifers. Two nutritional schedules: HG (n=4 heifers) and LG (n=4 heifers); one array per heifer; methylated enriched DNA (enriched) and total DNA (input) co-hybridyzed into each array Methylated-enriched DNA obtained from a methyl-CpG binding domain-based (MBD) protein assay

2016-02-11 | E-GEOD-77782 | biostudies-arrayexpress

Maternal Nutritional Status Modifies Heat-Associated Growth Restriction in Women with Chronic Malnutrition

Project description:Rising ambient temperatures represent an imminent risk to pregnant women and infants. Both maternal malnutrition and heat stress during pregnancy contribute to poor fetal growth, the leading cause of diminished child development in low-resource settings. However, studies explicitly examining interactions between these two important environmental factors are lacking. We leveraged maternal and neonatal anthropometry data from a randomized controlled trial focused on improving preconception maternal nutrition (Women First Preconception Nutrition trial) conducted in Thatta Pakistan, where both nutritional deficits and heat stress are prevalent. Multiple linear regression of ambient temperature and neonatal anthropometry at birth (n = 459) showed a negative association between daily maximal temperatures in the first trimester and z-scores of birth length (LGAZ) and head circumference (HCGAZ). Placental mRNA-sequencing and protein analysis showed transcriptomic changes in protein translation, ribosomal proteins and mTORC1 signalling components in term placenta exposed to excessive heat in the first trimester. Targeted metabolomic analysis indicated ambient temperature associated alterations in maternal circulation with decreases in choline concentrations. Notably, negative impacts of heat on birth length were in part mitigated in women randomized to comprehensive maternal nutritional supplementation (MNS) before pregnancy suggesting potential interactions between heat stress and nutritional status of the mother. Collectively the findings bridge critical gaps in our current understanding of how maternal nutrition may provide resilience against adverse effects of heat stress in pregnancy.

2023-02-08 | GSE220877 | GEO

Long noncoding RNA expression levels in BXPC-3 cells under different nutritional conditions.

Project description:In order to explore the relationship between long non-coding RNA expression and EMT in pancreatic cancer under different nutritional conditions, we carried out Microarray-based gene expression analysis.BXPC-3 cells were cultured under three conditions: nutrient-sufficient, low glucose and low glutamine for 48 hours and then long non-coding RNA Microarray-based gene expression analysis was carried out to observe the changes in long non-coding RNA expression, so as to explore the specific mechanism of EMT in pancreatic cancer cells under nutritional stress conditions.

2023-05-25 | GSE233113 | GEO

Gene expression changes in Laccaria bicolor mycelium grown under different nutritional conditions

Project description:Gene expression changes in Laccaria bicolor mycelium grown under different nutritional conditions

| PRJNA787211 | ENA

Escherichia coli transcriptome reorganization caused by nutritional changes

Project description:Escherichia coli transcriptome reorganization caused by nutritional changes

| PRJNA561298 | ENA

DNA methylation in the arcuate nucleus of heifers under two nutritional schedules

2016-02-11 | GSE77782 | GEO

Expression analysis of human PBMCs stimulated with Borrelia, MDP or Pam3cys.

Project description:Analysis examining the effect of the Crohn's disease-associated ATG16L1 polymorphism on the responses to stimulation components derived from various bacteria classes.

2015-06-30 | GSE68765 | GEO

Examining the role of mupirocin-induced nutritional stress in the S. aureus stringent stress response

Project description:Examining the role of mupirocin-induced nutritional stress in the S. aureus stringent stress response

| PRJNA433003 | ENA

Lysine acetylation of microbiome

Project description:This project study and comprehensively characterize the lysine acetyltion in the human gut microbiome using antibody-based enrichment strategry and Orbitrap mass spectrometer. The technique has also been applied to study the microbiome in pediatric Crohn's disease and control subjects in order to understand the functional alterations of microbiome in IBD.

2020-07-08 | PXD013427 | Pride

Development of Precision Neoadjuvant-Adjuvant Therapies

Project description:Development of Precision Neoadjuvant-Adjuvant Therapies

| PRJNA392769 | ENA