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WGS of LA-MRSA CC398

ABSTRACT: Genotypic characterization of LA-MRSA CC398 in pigsty visitors – Transient carriage or persistence?

PROVIDER: PRJEB33854 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR3466330_1.fastq.gz	Fastqsanger.gz
	ERR3466330_2.fastq.gz	Fastqsanger.gz
	ERR3466340_1.fastq.gz	Fastqsanger.gz
	ERR3466340_2.fastq.gz	Fastqsanger.gz
	ERR3466350_1.fastq.gz	Fastqsanger.gz

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WGS of LA-MRSA CC398

Project description:Genotypic characterization of LA-MRSA CC398 in pigsty visitors – Transient carriage or persistence?

| PRJEB33854 | ENA

LA-MRSA CC398 from UK animals

Project description:Livestock-associated methicillin resistant Staphylococcus aureus (LA-MRSA) CC398 isolated from UK animals belong to European lineages

| PRJEB14251 | ENA

Whole Genome Sequencing of CC398 LA-MRSA in UK

Project description:Whole Genome Sequencing of CC398 LA-MRSA in UK

| PRJEB25744 | ENA

Characterization of an early human-derived LA-MRSA CC398 isolate

Project description:Characterization of an early human-derived LA-MRSA CC398 isolate

| PRJEB27798 | ENA

The distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country.

Project description:Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S. aureus microarray (SAM-62) to compare genomes of isolates from three geographical areas (Belgium, Denmark, and Netherlands) to understand how CC398 colonizes different mammalian hosts. The core genomes of 44 pig isolates and 32 isolates from humans did not vary. However, mobile genetic element (MGE) distribution was variable including SCCmec. Phi3 bacteriophage and human specificity genes (chp, sak, scn) were found in invasive human but not pig isolates. SaPI5 and putative ruminant specificity gene variants (vwb and scn) were common but not pig specific. Virulence and resistance gene carriage was host associated but country specific. We conclude MGE exchange is frequent in CC398 and greatest among populations in close contact. This feature may help determine epidemiological associations among isolates of the same lineage. [Data is also available from http://bugs.sgul.ac.uk/E-BUGS-120]

2012-01-21 | E-BUGS-120 | biostudies-arrayexpress

MRSA CC398 in monkey faeces

Project description:Detection of MRSA CC398 in monkey faeces and its living environment.

| PRJEB42195 | ENA

LA-MRSA CC398 in Dairy Cattle and Veal Calf Farms Indicates Spillover From Pig Production.

Project description:The possible spillover from pigs into other production animals incites concern for unresolved reservoirs of human exposure. The present investigation was therefore initiated, to elucidate if Danish veal and dairy farms constitute a reservoir of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) CC398 and to potentially identify the source of introduction. We collected nasal swab samples from 17 Danish veal farms, 2 slaughterhouses, and received bulk tank milk samples from 286 dairy farms. All samples were analyzed by culturing and screening on MRSA selective plates and presumed MRSA was verified by MALDI-TOF and PCR. MRSA isolates were subjected to spa typing and whole-genome sequencing. LA-MRSA was found on two veal farms in one and three calves, respectively, with subsequent follow-up samples found negative. Eight of 286 dairy farms (2.8%) were found LA-MRSA positive and follow-up samples, from five farms showed intermittent detection of LA-MRSA. The spa types, t034 and t011, were the most common while a single isolate from a dairy farm belonged to spa type t843 associated to mecC-MRSA CC130 and is the first report of mecC-MRSA in the Danish dairy production. A phylogenetic analysis showed that some of the isolates grouped within or close to the dominant Danish pig clusters, suggesting spillover into cattle farms. Other isolates clustered outside the dominant pig clusters suggesting that other routes of introduction cannot be excluded. Results of the investigation indicated a contamination of veal farms while some dairy farms seemed to be a permanent reservoir. Thus, Danish cattle represent a low prevalence reservoir of LA-MRSA CC398, which at present, is not of major human health concern.

| S-EPMC6887863 | biostudies-literature

CC398 bloodstream infections in DK

Project description:Origin of LA-MRSA CC398 bloodstream infections and skin and soft tissue infections, Denmark

| PRJEB19505 | ENA

Emergence of CC398 MRSA in New Zealand

Project description:This study describes the emergence and evolution of CC398 MRSA in New Zealand

| PRJEB12552 | ENA

Comparision of La-RNA-binding between wild type La and sumoylation deficient La mutant (K41/200R) in HEK293 cells.

Project description:We performed a RNA immunoprecipitations experiments using gfp-specific antibodies to precipitate gfp-tagged La proteins from from gfp-La wild type and sumoylation deficient La mutant (K41/200R) cells and found that specific mRNAs are preferentially enriched gfp-La wild type RIPs when compared to sumoylation deficient La mutant (K41/200R) RIPs.

2017-11-22 | GSE102842 | GEO

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