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Transcriptome analysis of Candida albicans exposed to sub-inhibitory and inhibitory concentrations of tunicamycin

ABSTRACT: Transcriptome analysis of Candida albicans exposed to sub-inhibitory and inhibitory concentrations of tunicamycin

PROVIDER: PRJEB44666 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR5856250_1.fastq.gz	Fastqsanger.gz
	ERR5856250_2.fastq.gz	Fastqsanger.gz
	ERR5856242_1.fastq.gz	Fastqsanger.gz
	ERR5856242_2.fastq.gz	Fastqsanger.gz
	ERR5856243_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of Candida albicans exposed to sub-inhibitory and inhibitory concentrations of tunicamycin

Project description:We exposed log phase cells of C. albicans lab strain SC5314 to sub-inhibitory (1 µg/ml) and inhibitory (4 µg/ml) of tunicamycin for 1 h, then compared the transcriptome to the no drug treated cells.

2021-05-09 | E-MTAB-10391 | biostudies-arrayexpress

Whole genome sequencing of BG2 derived adaptors selected from sub-inhibitory amount of tunicamycin

Project description:Candida albicans lab strain BG2 was grown in YPD broth supplemented with 0.5ug/ml tunicamycin at 37C for 24h. We used three techinical repeats. The culture was washed, and diluted with distilled water. Then approximately 200 cells from each of the three cultures were spread on YPD plates. Randomly 99 colonies from each culture were tetsted for tolerance to tunicamycin, as compared to the parent BG2. In total we got 6 tolerant adaptors. These 6 adaptors as well as the parent were sequenced.

2022-12-11 | E-MTAB-12427 | biostudies-arrayexpress

Transcription profiling by array of Burkholderia cenocepacia J2315 wild type and antibiotic-resistant mutants exposed to sub-inhibitory concentrations of drugs

Project description:Burkholderia cenocepacia J2315 wild type and adaptive mutants with elevated resistance to antibiotics were exposed to sub-inhibitory concentrations of drugs

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Transcriptome analysis of Candida albicans exposed to sub-inhibitory amount of fluconazole

Project description:Transcriptome analysis of Candida albicans exposed to sub-inhibitory amount of fluconazole

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Kristen-PAO1 aerobic sub-inhibitory cond. tobramycin

Project description:To see the effect of sub-inhibitory concentrations of tobramycin on Pseudomonas aeruginosa grown under aerobic conditions. RNA was isolated form 4 biological repeats of P.aeruginosa grown to mid-log in cationic adjusted mueller hinton broth and 4 biological repeats of P.aeruginosa with the addition of 0.25ug/ml tobramycin in cationic adjusted mueller hinton broth. null

2011-03-30 | E-FPMI-23 | biostudies-arrayexpress

Transcriptome analysis of Candida auris response to tunicamycin

Project description:Candida auris reference strain B11221 was exposed to sub-inhibitory (1μg/ml) and inhibitory (8μg/ml) tunicamycin for 3h. Transcriptomes were compared to no drug treatment control.

2023-12-23 | E-MTAB-12667 | biostudies-arrayexpress

Whole genome sequencing of Candida albicans tunicamycin adaptors

Project description:We used Candida albicans lab strain SC5314 to obtain tunicamycin adaptors. We did whole genome sequencing of the adaptors and the parent as well.

2021-04-24 | E-MTAB-10358 | biostudies-arrayexpress

Genome location dictates the transcriptional response to sub-inhibitory concentrations of PolC-inhibitors in Clostridium difficile

Project description:Genome location dictates the transcriptional response to sub-inhibitory concentrations of PolC-inhibitors in Clostridium difficile

| PRJNA478856 | ENA

Genome location dictates the transcriptional response to sub-inhibitory concentrations of PolC-inhibitors in Clostridium difficile

Project description:Clostridium difficile is a potentially lethal gut pathogen that causes nosocomial and community acquired infections. Limited treatment options and reports of reduced susceptibility to current treatment emphasize the necessity for novel antimicrobials. The DNA-polymerase of gram-positive organisms is an attractive target for the development of antimicrobials. ACX362E (N2-(3,4-Dichlorobenzyl)-7-(2-[1-morpholinyl]ethyl)guanine; MorE-DCBG) is a DNA polymerase inhibitor in pre-clinical development as a novel therapeutic against C. difficile infection. This synthetic purine shows preferential activity against C. difficile Pol IIIC over those of other organisms in vitro and is effective in an animal model of C. difficile infection. In this study we have determined its efficacy against a large collection of clinical isolates. At concentrations below the minimal inhibitory concentration, the presumed slowing (or stalling) of replication forks due to ACX362E leads to a growth defect. We have determined the transcriptional response of C. difficile to replication inhibition and observed an overrepresentation of up-regulated genes near the origin of replication in the presence of PolC-inhibitors, but not when cells were subjected to sub-inhibitory concentrations of other antibiotics. This phenomenon can be explained by a gene dosage shift, as we observed a concomitant increase in the ratio between origin-proximal versus terminus-proximal gene copy number upon exposure to PolC-inhibitors. Moreover, we show that certain genes differentially regulated under PolC-inhibition are controlled by the origin-proximal general stress response regulator sigma factor B. Together, these data suggest that genome location both directly and indirectly determines the transcriptional response to replication inhibition in C. difficile

2018-07-03 | GSE116503 | GEO

Gene expression data from Pseudomonas aeruginosa PAO1 and mutator (Δ mutS) evolved for 940 generations in LB with and without sub-inhibitory concentrations of ciprofloxacin (0.05µg/ml)

Project description:Gene expression of P. aerruginosa changes after short-term exposure to ciprofloxacin at sub-inhibitory concentrations but the effect of long-term exposure which select for the most fitted subpopulations is not known. We used microarrays to investigate the changes in gene expression of P.aeruginosa PAO1 and mutator (Δ mutS) after long-term evolution (94 daily passages) in LB in the presence and absence of ciprofloxacin

2016-02-25 | GSE78255 | GEO

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