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Transcriptome analysis of Candida albicans exposed to sub-inhibitory amount of fluconazole

ABSTRACT: Transcriptome analysis of Candida albicans exposed to sub-inhibitory amount of fluconazole

PROVIDER: PRJEB53946 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR9883764.fastq.gz	Fastqsanger.gz
	ERR9883765.fastq.gz	Fastqsanger.gz
	ERR9883766.fastq.gz	Fastqsanger.gz
	ERR9883767.fastq.gz	Fastqsanger.gz
	ERR9883768.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of Candida albicans exposed to sub-inhibitory amount of fluconazole

Project description:Candida albicans lab strain SC5314 was exposed to 0.5ug/ml fluconazole for 3h. Transcriptome was compared to no drug control.

2022-07-08 | E-MTAB-11881 | biostudies-arrayexpress

Whole genome sequencing of adaptors derived from exposure to low amount of fluconazole in Candida albicans

Project description:Candida albicans lab strain SC5314 was exposued to sub-inhibitory amount (0.5 ug/ml) fluconazole for 24h. Two tolerant adaptors (FY1284 and FY1285) were obtained. The adaptors were unstable on YPD plate, yielding small (S) and large (L) colonies. The small (FY1284-S and FY1285-S) and the large (FY1284-L and FY1285-L) colonies were sequenced

2022-07-18 | E-MTAB-11923 | biostudies-arrayexpress

Transcriptome analysis of Candida albicans exposed to sub-inhibitory and inhibitory concentrations of tunicamycin

Project description:We exposed log phase cells of C. albicans lab strain SC5314 to sub-inhibitory (1 µg/ml) and inhibitory (4 µg/ml) of tunicamycin for 1 h, then compared the transcriptome to the no drug treated cells.

2021-05-09 | E-MTAB-10391 | biostudies-arrayexpress

Transcriptome analysis of Candida albicans exposed to sub-inhibitory and inhibitory concentrations of tunicamycin

Project description:Transcriptome analysis of Candida albicans exposed to sub-inhibitory and inhibitory concentrations of tunicamycin

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Project description:QUANT-seq approach was utilized to determine the gene expression in the transcriptome of C. albicans treated with the solvent control DMSO or the antifungal drug fluconazole (FLC). Biological triplicates of C. albicans grown in YPD medium treated with either DMSO or 3 µg/ml fluconazole for 30 minutes at 37˚C were harvested and total RNA was isolated using standard procedures (hot phenol method).

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Gene expression in response to fluconazole vs. the combination of fluconazole and osthole

Project description:Transcriptional profiling of Candida albicans comparing fluconazole treated cells with fluconazole and osthole treated cells

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Mistranslation accelerates the adaptation of Candida albicans to Fluconazole

Project description:The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the presence and absence of the antifungal drug fluconazole. Elevated levels of mistranslation resulted in the rapid acquisition of resistance to fluconazole.

2016-10-27 | E-SYBR-13 | biostudies-arrayexpress

Gene expression in response to fluconazole vs. the combination of fluconazole and berberine

Project description:Transcriptional profiling of Candida albicans comparing fluconazole treated cells with fluconazole- and berberine-treated cells, as well untreated cells with berberine treated cells

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The early transcriptional and post-transcriptional responses to fluconazole in sensitive and resistant Candida albicans (RNA-Seq)

Project description:Candida albicans is a leading cause of fungal infections in immunocompromised patients. Management of candidemia relies on a few antifungal agents, with fluconazole being first line therapy. The emergence of fluconazole-resistant strains highlights the pressing need to improve our molecular understanding of the drug response mechanisms. By sequencing the 5’P mRNA degradation intermediates, we show that co-translational mRNA decay is common in C. albicans and characterize how in vivo 5´-3´ exonuclease degradation trails the last translating ribosome. Thus, the study of the 5'P mRNA degradome (5PSeq) offers a simple and affordable way to measure ribosome dynamics and identify codon specific ribosome stalls in response to drugs and amino acid deprivation. Building upon this, we combine RNA-Seq and 5PSeq to study the early response of sensitive and resistant C. albicans isolates to fluconazole. Our results highlight that transcriptional responses, rather than changes in ribosome dynamics, are the main driver of Candida resistance to fluconazole.

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