Project description:This SuperSeries is composed of the following subset Series: GSE33010: Human-specific patterns of gene expression in the brain (Arrays) GSE33587: Human-specific patterns of gene expression in the brain (RNA-Seq) Refer to individual Series
Project description:We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque. DpnII tag-based libraries were generated from human, chimpanzee, and rhesus macaque brain (frontal pole, hippocampus, caudate nucleus), and sequenced using an Illumina Genome Analyzer.
Project description:We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque Comparative gene expression in human, chimpanzee, and rhesus macaque brain
Project description:We leveraged single nuclei RNA-seq from 192 human brain samples to map cis-eQTLs in 8 brain cell types. We found extensive cell-type specific genetic effect on gene expression and integrated our results with GWAS to identify putative novel risk genes for brain disorders and the cell types in which the disease mechanisms are likely active.