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Human-specific patterns of gene expression in the brain (RNA-Seq)

ABSTRACT: We identified human-specific gene expression patterns in the brain by comparing expression with chimpanzee and rhesus macaque. DpnII tag-based libraries were generated from human, chimpanzee, and rhesus macaque brain (frontal pole, hippocampus, caudate nucleus), and sequenced using an Illumina Genome Analyzer.

ORGANISM(S): Pan troglodytes

SUBMITTER: Genevieve Konopka

PROVIDER: E-GEOD-33587 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution.

Zeng Jia J Konopka Genevieve G Hunt Brendan G BG Preuss Todd M TM Geschwind Dan D Yi Soojin V SV

American journal of human genetics 20120823 3

DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin regulation and gene expression. To date, it remains largely unknown how patterns of DNA methylation differ between closely related species and whether such differences contribute to species-specific phenotypes. To investigate these questions, we generated nucleotide-resolution whole-genome methylation maps of the prefrontal cortex of multiple humans and chimpanzees. Levels and patterns of DNA methylation v ...[more]

PMID: 22922032

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