Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Long noncoding RNA as putative biomarkers for protstate cancer detection

ABSTRACT: Long noncoding RNA as putative biomarkers for protstate cancer detection

PROVIDER: PRJNA241295 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Assessment Of Long Noncoding RNA CCAT1 In Colorectal Cancer Patients

Project description:1. Evaluate the diagnostic value of long noncoding RNA (CCAT1) expression by RT-PCR in peripheral blood in colorectal cancer patients versus normal healthy control personal. 2. Evaluate the clinical utility of detecting long noncoding RNA (CCAT1) expression in diagnosis of colorectal cancer patients & its relation to tumor staging. 3. Evaluate the clinical utility of detecting long noncoding RNA (CCAT1) expression in precancerous colorectal diseases. 4. Compare long noncoding RNA (CCAT1) expression with traditional marker; carcinoembryonic antigen (CEA) and Carbohydrate antigen 19-9 (CA19-9) in diagnosis of colorectal cancer.

| 2330122 | ecrin-mdr-crc

Long noncoding RNA as putative biomarkers for protstate cancer detection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-10-17 | E-GEOD-55910 | biostudies-arrayexpress

Detection of RNA–DNA binding sites in long noncoding RNAs

Project description:Detection of RNA–DNA binding sites in long noncoding RNAs

| PRJNA489807 | ENA

Long noncoding RNA as putative biomarkers for protstate cancer detection

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-10-17 | GSE55910 | GEO

Long noncoding RNAs as putative biomarkers for prostate cancer detection.

Project description:Prostate cancer is one of the leading causes of mortality among US males. There is an urgent unmet need to develop sensitive and specific biomarkers for the early detection of prostate cancer to reduce overtreatment and accompanying morbidity. We identified a group of differentially expressed long noncoding RNAs in prostate cancer cell lines and patient samples and further characterized six long noncoding RNAs (AK024556, XLOC_007697, LOC100287482, XLOC_005327, XLOC_008559, and XLOC_009911) in prostatic adenocarcinoma tissue samples (Gleason score >6.0) and compared them with matched normal (healthy) tissues. Interestingly, these markers were also successfully detected in patient urine samples and were found to be up-regulated when compared with normal (healthy) urine. AK024556 (SPRY4-IT1) was highly up-regulated in human prostate cancer cell line PC3 but not in LNCaP, and siRNA knockdown of SPRY4-IT1 in PC3 cells inhibited cell proliferation and invasion and increased cell apoptosis. Chromogenic in situ hybridization assay was developed to detect long noncoding RNAs in primary prostatic adenocarcinoma tissue samples, paving the way for clinical diagnostics. We believe that these results will set the stage for more extensive studies to develop novel long noncoding RNA-based diagnostic assays for early prostate cancer detection and will help to distinguish benign prostate cancer from precancerous lesions.

| S-EPMC4210464 | biostudies-literature

Long noncoding RNA as putative biomarkers for protstate cancer detection [Set 1]

Project description:To identify which lncRNAs are differentially expressed in prostate cancer, total RNA from prostate cancer cell line, PC3, and normal epithelial prostatic cells were screened using NCode (Life Technologies) . The NCode microarray is designed to interrogate 12,784 lncRNAs and 25,409 mRNA target protein-coding genes. Gene expression in prostate epithelial cells and PC3 was measured. Three independent experiments (biological replicates) were performed.

2014-10-17 | E-GEOD-55908 | biostudies-arrayexpress

Long noncoding RNA as putative biomarkers for protstate cancer detection [Set 2]

Project description:To identify which lncRNAs are differentially expressed in prostate cancer, the total RNA from prostate cancer cell lines (PC3, LNCaP), normal epithelial prostatic cells and the pool of 10 prostate tumor tissues and 10 adjacent normal prostate tissues were screened using SurePrint G3 human lncRNA microarrays (Agilent). The SurePrint G3 Human Gene array contains 16,472 lincRNAs and 34,127 mRNA genes. Gene expression in prostate cell lines and pooled tissue samples was measured. Three independent experiments (biological replicates) for cell lines (epithelial cells, PC3 and LNCap) and two independent experiments (technical replicates) for pooled prostate tissues (tumor and adjacent normal) samples were performed.

2014-10-17 | E-GEOD-55909 | biostudies-arrayexpress

Long noncoding RNA as putative biomarkers for protstate cancer detection [Set 1]

2014-10-17 | GSE55908 | GEO

Long noncoding RNA as putative biomarkers for protstate cancer detection [Set 2]

2014-10-17 | GSE55909 | GEO