Project description:Single strand consensus sequencing reveals that HIV type but not subtype significantly impacts viral mutation frequencies and spectra
Project description:Antiretroviral treatment regimens can effectively control HIV replication and some aspects of disease progression. However, molecular events in end-organ diseases such as central nervous system (CNS) disease are not yet fully understood, and routine eradication of latent reservoirs is not yet in reach. Regulatory RNAs have emerged as important participants in HIV disease pathogenesis. Using brain tissue from the simian immunodeficiency virus (SIV) model of HIV disease, we profiled messenger RNAs (mRNAs) and circular RNAs (circRNAs), seeking to identify possible networks of RNA interaction in SIV infection and neuroinflammation.
Project description:Although mitochondrial DNA single nucleotide polymorphisms have been associated with Parkinsons disease their functional effects are unclear. Here, we functionalized a PD-associative mtSNP and found that it affects a mitochondrial-derived peptide MDP.
Project description:Hair shaft is one of the most common biological evidences found at crime scene. Due to the low amount and high degradation of nuclear DNA in hair shaft, it is difficult to achieve individual identification through routine method. The proteins in the hair shaft are stable and contain genetic polymorphisms in the form of single amino acid polymorphisms (SAPs), translated from non-synonymous single nucleotide polymorphisms (nsSNPs) in the genome.
