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Mus musculus

ABSTRACT: RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

PROVIDER: PRJNA312769 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3181010.fastq.gz	Fastqsanger.gz
	SRR3181011.fastq.gz	Fastqsanger.gz
	SRR3181012.fastq.gz	Fastqsanger.gz
	SRR3181013.fastq.gz	Fastqsanger.gz
	SRR3181014.fastq.gz	Fastqsanger.gz

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RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

Project description:RNA-Seq of subcutaneous inguinal white fat of Hlx transgenic mice and littermate controls.

2017-08-11 | GSE78143 | GEO

Interaction between PPARγ and mTORC1 in the regulation of inguinal white adipose tissue transcriptome

Project description:Purpose: To investigate the involvement of mTORC1 as a mediator of the actions of the PPARγ ligand rosiglitazone in subcutaneous inguinal white adipose tissue transcriptome; Methods: Mice bearing regulatory associated protein of mTOR (Raptor) deletion and therefore mTORC1 deficiency exclusively in adipocytes (adiponectin Cre recombinase) and littermate controls were fed a high-fat diet supplemented or not with the PPARγ agonist rosiglitazone (30 mg/kg/day) for 8 weeks and evaluated for inguinal white adipose tissue transcriptome (Rnaseq); Results: 3,2425 genes had their correspondent mRNA levels altered by either adipocyte Raptor deficiency or rosiglitazone administration or their combination. Among those, 408 genes modulated by rosiglitazone required mTORC1. Conclusion: PPARγ and mTORC1 are essential partners in the regulation of a cluster of genes in inguinal white adipose tissue.

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