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Caenorhabditis elegans

ABSTRACT: RNA-seq analysis of hsf-1 mutant in C. elegans larval development

PROVIDER: PRJNA321851 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3535780.fastq.gz	Fastqsanger.gz
	SRR3535790.fastq.gz	Fastqsanger.gz
	SRR3535781.fastq.gz	Fastqsanger.gz
	SRR3535791.fastq.gz	Fastqsanger.gz
	SRR3535782.fastq.gz	Fastqsanger.gz

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Project description:To understand the function and regulation of the C. elegans heat shock factor (HSF-1) in larval development, we have used ChIP-seq to analyze the occupancy of HSF1 and RNA Pol II in L2 larvae and young adult (YA) animals grown at 20°C or upon heat shock at 34°C for 30 min. In addition, we have used RNA-seq to analyze the transcriptomes of wild type (N2), hsf-1(ok600) mutants and hsf-1(ok600); rmSi1[hsf-1::gfp] L2 larvae grown at 20°C and characterized the gene expression change by heat shock in wild type (N2), hsf-1(sy441) and hsf-1(sy441);rmSi1[hsf-1::gfp] animals at L2 stage.

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Project description:Extensive oscillatory gene expression during C. elegans larval development [Ribosome footprinting]

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Age-dependent heat shock hormesis to HSF-1 deficiency suggests a compensatory mechanism mediated by the unfolded protein response and innate immunity in young Caenorhabditis elegans

Project description:The goal of this RNA-Seq analysis was to identify genes differentially expressed in wild type (N2) and a hypomorphic mutant of the gene encoding heat shock factor 1 {hsf-1(sy441)} at normal conditions and upon heat shock. This study aimed to identify genes that are up- or downregulated when HSF-1 activity is impaired at 20 ºC. We also aimed to identify gene that are regulated by HSF-1 upon heat stress by comparing differentially expressed genes upon heat shock in wild type and in hsf-1(sy441) mutant background.

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