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Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

ABSTRACT: Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

PROVIDER: PRJNA325276 | ENA |

REPOSITORIES: ENA

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Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (mouse) Studies in Single Day Study using Illumina Array

Project description:The goal of this project was to determine gene expression changes in the liver at different times post treatment with the common freshwater cyanobacterial toxin, cylindrospermopsin (CYN). The liver is generally considered to be the primary target of this toxin and all the data has been derived from livers of exposed animals as well as concurrent controls. Preliminary gene expression effects have been reported (Chernoff et al., 2010) and the current data extend the time course from 1 hour post exposure to 1-day post cessation of a 5-day period dosing period. Gene expression changes were determined in the livers of pregnant mice exposed to toxic levels of cyanobacterial toxin, cylindrospermopsin. Animals were exposed to a dose of CYN that elicited significant hepatic toxicity. This single dose study analyzed liver samples collected at 1, 3, 6, 12 and 24 hours post dose. Gene expression changes were analyzed on the Illumina MouserRef-8v2.0 expression beadchip.

2016-06-24 | E-GEOD-83197 | biostudies-arrayexpress

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Single Day Study using Affymetrix Array

2016-06-24 | E-GEOD-83199 | biostudies-arrayexpress

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Multi-day Study using Affymetrix Array

Project description:The goal of this project was to determine gene expression changes in the liver at different times post treatment with the common freshwater cyanobacterial toxin, cylindrospermopsin (CYN). The liver is generally considered to be the primary target of this toxin and all the data has been derived from livers of exposed animals as well as concurrent controls. Preliminary gene expression effects have been reported (Chernoff et al., 2010) and the current data extend the time course from 1 hour post exposure to 1-day post cessation of a 5-day period dosing period. Gene expression changes were determined in the livers of pregnant mice exposed to toxic levels of the cyanobacterial toxin, cylindrospermopsin. Animals were exposed to a dose of CYN that elicited significant hepatic toxicity. This multi-day study used tissue obtained 1-day, 2-days, 4-days, and 5-days after the initiation of a 5 consecutive day dosing regimen. Toxicity data including gross observations, necropsy findings and clinical chemistry endpoints indicative of hepatic, renal and homeostasis functions were collected at the same time liver tissues for gene expression analysis were obtained. Gene expression changes were analyzed on the GeneChipÂ® Mouse Genome 430 2.0 Array.

2016-06-24 | E-GEOD-83198 | biostudies-arrayexpress

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Single Day Study using Affymetrix Array

2016-06-24 | GSE83199 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (Mouse) Studies in Multi-day Study using Affymetrix Array

2016-06-24 | GSE83198 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animal (mouse) Studies in Single Day Study using Illumina Array

2016-06-24 | GSE83197 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-06-24 | GSE83201 | GEO

Adverse Health Effects of Cylindrospermopsin in Laboratory Animals (mouse) Studies

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-06-24 | E-GEOD-83201 | biostudies-arrayexpress

Comparative analysis of transcriptional profiles of adult Schistosoma japonicum from different laboratory animals and the natural host, water buffalo

Project description:Although numerous researches on schistosomiasis japonica have been performed using laboratory animal models, the comparison of gene expression profiles of S. japonicum from the different laboratory animals and natural hosts is still a gap. We systematically compared the gene expression profiles of schistosomes from different laboratory animals and water buffaloes. The findings of this study provide the basis for schistosomiasis research in different mammalian hosts at transcriptional level and valuable resource for the screening of anti-schistosomal intervention targets.

2015-07-19 | GSE65327 | GEO

Intermittent calorie restriction largely counteracts the adverse health effects of a moderate-fat diet in aging C57BL/6J mice

Project description:Calorie restriction (CR) has been shown to extend life- and health-span in model species. For most humans, a life-long CR diet is too arduous to adhere to. The aim of this study was to explore whether weekly intermittent CR can 1) provide long-term beneficial effects and 2) counteract diet-induced obesity in male aging mice. In this study, we have exposed C57Bl/6J mice for 24 months to an intermittent (INT) diet, alternating weekly between CR of a control diet and ad libitum moderate-fat (MF) feeding. This weekly intermittent CR significantly counteracted the adverse effects of the MF diet on mortality, body weight and liver health markers in male 24-month-old mice. Hepatic gene expression profiles of INT-exposed animals appeared much more comparable to CR than to MF-exposed mice. At 12 months of age, a subgroup of MF-exposed mice was transferred to the INT diet. Gene expression profiles in the liver of the 24-month-old diet switch mice were highly similar to the INT-exposed mice. However, a small subset of genes was consistently changed by the MF diet during the first phase of life. Weekly intermittent CR largely, but not completely, reversed adverse effects caused by a MF diet.

2017-01-16 | GSE93642 | GEO

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