Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Leucoraja erinacea

ABSTRACT: RNASeq of molecular basis of ancestral vertebrate electroreception

PROVIDER: PRJNA361222 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5172150_1.fastq.gz	Fastqsanger.gz
	SRR5172150_2.fastq.gz	Fastqsanger.gz
	SRR5172151_1.fastq.gz	Fastqsanger.gz
	SRR5172151_2.fastq.gz	Fastqsanger.gz
	SRR5172152_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

Leucoraja erinacea

Project description:Leucoraja erinacea Raw sequence reads

| PRJNA358112 | ENA

Leucoraja erinacea

Project description:The little skate is native to the western Atlantic Ocean

| PRJNA13033 | ENA

Leucoraja erinacea

Project description:Leucoraja erinacea Transcriptome or Gene expression

| PRJNA288370 | ENA

Leucoraja erinacea

Project description:The little skate is native to the western Atlantic Ocean

| PRJNA13631 | ENA

Leucoraja erinacea

Project description:EST project located at the Mount Desert Island Biological Laboratory

| PRJNA13346 | ENA

Leucoraja erinacea

Project description:Transcriptome of the Ampullae of Lorenzini in Leucoraja erinacea

| PRJNA550453 | ENA

Leucoraja erinacea

Project description:Leucoraja erinacea genome sequencing project

| PRJNA60893 | ENA

Adult chondrogenesis and spontaneous cartilage repair in the skate, Leucoraja erinacea.

Project description:Mammalian articular cartilage is an avascular tissue with poor capacity for spontaneous repair. Here, we show that embryonic development of cartilage in the skate (Leucoraja erinacea) mirrors that of mammals, with developing chondrocytes co-expressing genes encoding the transcription factors Sox5, Sox6 and Sox9. However, in skate, transcriptional features of developing cartilage persist into adulthood, both in peripheral chondrocytes and in cells of the fibrous perichondrium that ensheaths the skeleton. Using pulse-chase label retention experiments and multiplexed in situ hybridization, we identify a population of cycling Sox5/6/9+ perichondral progenitor cells that generate new cartilage during adult growth, and we show that persistence of chondrogenesis in adult skates correlates with ability to spontaneously repair cartilage injuries. Skates therefore offer a unique model for adult chondrogenesis and cartilage repair and may serve as inspiration for novel cell-based therapies for skeletal pathologies, such as osteoarthritis.

| S-EPMC7217701 | biostudies-literature

Base-resolution DNA methylation maps of little skate (Leucoraja erinacea)

Project description:Using MetylC-seq we investigated single-base resolution methylomes of embryonic and adult pelvic and pectoral fins of little skate.

2022-12-31 | GSE190730 | GEO

A role for the CXCR4-CXCL12 axis in the little skate, Leucoraja erinacea.

Project description:The interaction between C-X-C chemokine receptor type 4 (CXCR4) and its cognate ligand C-X-C motif chemokine ligand 12 (CXCL12) plays a critical role in regulating hematopoietic stem cell activation and subsequent cellular mobilization. Extensive studies of these genes have been conducted in mammals, but much less is known about the expression and function of CXCR4 and CXCL12 in non-mammalian vertebrates. In the present study, we identify simultaneous expression of CXCR4 and CXCL12 orthologs in the epigonal organ (the primary hematopoietic tissue) of the little skate, Leucoraja erinacea. Genetic and phylogenetic analyses were functionally supported by significant mobilization of leukocytes following administration of Plerixafor, a CXCR4 antagonist and clinically important drug. Our results provide evidence that, as in humans, Plerixafor disrupts CXCR4/CXCL12 binding in the little skate, facilitating release of leukocytes into the bloodstream. Our study illustrates the value of the little skate as a model organism, particularly in studies of hematopoiesis and potentially for preclinical research on hematological and vascular disorders.

| S-EPMC6139610 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data