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Heme and GATA1 coordinately regulate erythroid differentiation

ABSTRACT: Heme and GATA1 coordinately regulate erythroid differentiation

PROVIDER: PRJNA374843 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5258040.fastq.gz	Fastqsanger.gz
	SRR5258050.fastq.gz	Fastqsanger.gz
	SRR5258060.fastq.gz	Fastqsanger.gz
	SRR5258070.fastq.gz	Fastqsanger.gz
	SRR5258080.fastq.gz	Fastqsanger.gz

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Heme and GATA1 coordinately regulate erythroid differentiation [expression]

Project description:In mice lacking the heme exporter, FLVCR, differentiation fails at the CFU-E/proerythroblast stage from excessive heme and reactive oxygen species. We show that Flvcr1-deleted CFU-E/proerythroblasts have low GATA1 mRNA and GATA1-target gene mRNAs along with increased ribosomal protein mRNAs as a direct result of increased heme. Thus heme increases ribosomal protein transcription when globin production needs to be increased, and when heme is excessive, GATA1 is reduced allowing for normal termination of erythroid differentiation. This demonstrates that heme and GATA1 are co-master regulators of erythroid differentiation.

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GATA-1 and heme regulate the erythroid cell transcriptome.

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