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Expression data from endothelial cells induced from bone marrow mesenchymal stem cells with SCD1 overexpression

ABSTRACT: Expression data from endothelial cells induced from bone marrow mesenchymal stem cells with SCD1 overexpression

PROVIDER: PRJNA417317 | ENA |

REPOSITORIES: ENA

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Expression data from endothelial cells induced from bone marrow mesenchymal stem cells with SCD1 overexpression

Project description:Bone marrow mesenchymal stem cells (BM-MSCs) are of multi-differentiating potential and has been demonstrated to have the ability to differentiate into endothelial cells. Stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in lipid metabolism, which can convert saturated fatty acids into unsaturated fatty acids. We used lentivirus to transfected SCD1 gene into BM-MSCs and found that overexpression of SCD1 could promote the differentiation of BM-MSCs into endothelial cells. We used microarrays to detect the differential gene expression profile of endothelial induced BM-MSCs with SCD1 overexpression.

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Expression data in HCT-116 colon cancer cell treated with SCD1 inhibitor or in SCD1 knocked out HCT-116 cell

Project description:To understand molecular mechanisms underlying the growth inhibitory ativity of Stearoyl-CoA desaturase-1 (SCD1) inhibitor, we performed microarray analysis using HCT-116 colorectal cancer cells, in which SCD1 was pharmacologically blocked or genetically ablated.

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RNA sequencing analysis of wild-type and Scd1-deficient CD4+ naïve T cells

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