Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The role of MLL1 in post natal myogenesis

ABSTRACT: The role of MLL1 in post natal myogenesis

PROVIDER: PRJNA423228 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

The role of MLL1 in post natal myogenesis

Project description:The trithorax H3K4 histone methyltransferase (HMT) MLL1 has important roles for early embryonic development, hematopoiesis and neurogenesis through regulation of Hox and homeodomain factor expression. MLL1 has been previously implicated in activation of Myf5 expression through an interaction with Pax7. Here, we find that in vivo, MLL1 is necessary for efficient muscle regeneration, and for maintenance of muscle stem and progenitor cells. Loss of MLL1 in cultured myoblasts reveals an essential role for proliferation and expression of both Myf5 and Pax7. Loss of Myf5 is conditional on loss of Pax7 and exogenous Pax7 rescues Myf5 in the absence of MLL1 suggesting a role for MLL1 in Pax7 expression but not Pax7 activity. Importantly, Mll1 knockout results in a minor decrease to H3K4me3 at Pax7, a 40% decrease in Pax7 mRNA and an 85% decrease in Pax7 protein, suggesting a previously proposed non-HMT role for MLL1 may involve linking transcription to translation.

2019-08-16 | GSE108339 | GEO

The role of fibronectin in the post natal lens

Project description:The role of fibronectin in the post natal lens

| PRJNA490544 | ENA

Expression data from post-natal rat Achilles tendons

Project description:We have compared the gene expression profile of post-natal 1 day and 7 day rat Achilles tendons.

2015-07-10 | GSE70459 | GEO

Expression data from pre natal and post natal CCAM samples and relative controls

Project description:This study aims at giving an insight on gene expression in CCAM. Keywords: disease state analysis A total of 14 microarrays were completed. Samples were divided into four groups: Fetal CCAM samples (n=4), fetal control samples (n=2), post-natal CCAM samples (n=5), post-natal control samples (n=3)

2007-05-04 | E-GEOD-4772 | biostudies-arrayexpress

Expression data from post-natal rat Achilles tendons

Project description:We have compared the gene expression profile of post-natal 1 day and 7 day rat Achilles tendons. Post-natal 1 day and 7 day rat Achilles tendons were collected. Each sample contains at least two individuals. Total RNA was extracted and fragmented biotin-tagged cRNA was hybridized to Rat Genome 230 2.0 Array.

2015-07-10 | E-GEOD-70459 | biostudies-arrayexpress

Gene expression profiling of mouse sclera during post-natal development

Project description:Although there have been studies conducted on cornea and retina growth and development, postnatal gene expression studies on sclera growth during postnatal growth has not been well characterised. Given that the mouse genome has 85% homology to the human genome and has been completely sequenced, mouse model for the study of ocular growth has advantages over other animal models. Thus, we aimed to study the biology and genetics behind sclera growth during post-natal development in Balb/cJ mice as a means to understand genetic changes that cause scleral growth and development during post-natal eye development The purpose of this study was to identify the genes underlying the development of mouse sclera post-natal growth of the posterior chamber of the eye using microarray

2011-03-22 | GSE28056 | GEO

Post-natal meningeal macrophages protect against viral neuroinfection

Project description:Post-natal meningeal macrophages protect against viral neuroinfection

| PRJNA784952 | ENA

Impact of control interventions on lung gene expression in post-natal lung development

Project description:During the studies of post-natal lung development in the laboratory C57BL/6 mouse, broad spectrums of interventions are applied by intraperitoneal (i.p.) injections. We explored whether injection of saline, tamoxifen, “scrambled” antagomiRs (to control studies that target microRNA with antagomiRs), migloyl or water, in well-established protocols, had any impact on the post‑natal gene expression in mouse lungs.

2017-10-02 | GSE92891 | GEO

Expression data from human embryonic (9-12w) and post-natal livers

Project description:The liver is a multifunctional organ, which undergoes rapid changes during the developmental period and relies on tightly-regulated gene expression. Little is known regarding the complex expression patterns of mRNAs during the early stages of human liver development in comparison to post-natal livers. We used microarrays to detail the global programme of gene expression during liver development following specification, at the stage of proliferation and differentiation when compared to post-natal livers, and identified distinct classes of up-regulated and downregulated genes during this process.

2009-10-01 | GSE15238 | GEO

Chromatin immunoprecipitation of human MLL1 to understand its role in cell type specification

Project description:An experiment was performed to understand its role in cell type specification, we have determined the human genomic binding sites of MLL1. MLL1 localizes with Pol II to the 5' end of actively transcribed genes, where histone H3 lysine 4 (H3-K4) trimethylation occurs. The ability of MLL1 to serve as a start site-specific global transcriptional regulator and to participate in larger chromatin domains at the Hox genes reveals the dual roles MLL1 plays in maintenance of cellular identity.

2005-06-03 | E-WMIT-4 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data