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MHOR002 expression: Forkhead box O transcription factors both suppress and support breast cancer progression.

ABSTRACT: MHOR002 expression: Forkhead box O transcription factors both suppress and support breast cancer progression.

PROVIDER: PRJNA428923 | ENA |

REPOSITORIES: ENA

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MHOR002 expression: Forkhead box O transcription factors both suppress and support breast cancer progression.

Project description:FOXOs are regulators of cellular homeostasis and putative tumor suppressors. The role of FOXOs in cancer progression remains to be determined however as the data on FOXO function in cancer are fragmentary and come from studies that focused on isolated aspects of cancer, especially for epithelial cancers. To clarify the role of FOXOs in epithelial cancer progression we characterized the effects of inducible FOXO activation and loss in a mouse model of metastatic invasive lobular carcinoma. Strikingly, either activation or loss of FOXO function suppresses tumor growth and metastasis. We show that the multitude of cellular processes critically affected by FOXO function including proliferation, survival, redox homeostasis and PI3K-signaling need to be carefully balanced for tumor cells to thrive.

2018-02-11 | GSE108842 | GEO

Effect of forkhead box M1 in multiple myeloma

Project description:Effect of forkhead box M1 in multiple myeloma

| PRJNA746277 | ENA

Forkhead box E1 (FOXE1) RNAis vs control RNAi in HEKa cells

Project description:Analysis of HEKa cells depleted of Forkhead box E1 (FOXE1). FOXE1 is induced in psoriasis lesions and promotes keratinocytes. Results provide insight into the downstream targets of FOXE1 function in psoriasis.

2021-01-09 | GSE164438 | GEO

Forkhead box F1 overexpression initiates Barrett’s like metaplasia by promoting trans-differentiation and wound repair

Project description:The forkhead box (FOX) family of transcriptional regulators is characterized by a distinct forkhead DNA-binding domain11. FOXF1 gene is highly conserved across species and implicated in embryonic digestive tract morphogenesis. In an in-vitro established model, normal esophageal squamous cells, EPC2, were transfected with FOXF1 to determine pathways regulated by FOXF1 during the squamous to columnar change in cells.

2021-11-12 | GSE122481 | GEO

Forkhead box Q1-regulated transcriptome in human breast cancer cells

Project description:Forkhead box Q1-regulated transcriptome in human breast cancer cells

| PRJNA634524 | ENA

Identification of a forkhead box protein transcriptional network induced in human neutrophils in response to inflammatory stimuli

Project description:We performed the first RNAseq analysis of human primary neutrophils exposed to lipopolysaccharide which revealed a robustly enhanced transcriptional network driven by forkhead box (FOX) transcription factors.

2023-01-02 | GSE221866 | GEO

Forkhead box E1 (FOXE1) RNAis vs control RNAi in HEKa cells

Project description:Forkhead box E1 (FOXE1) RNAis vs control RNAi in HEKa cells

| PRJNA690714 | ENA

Effect of forkhead box M1 in multiple myeloma

Project description:Forkhead Box M1 (FOXM1) is a promising molecular target for high-risk multiple myeloma and relapse and refractory myeloma, but whether FOXM1 is essential in myeloma has not yet been established. To address this knowledge gap, we used Western blotting to measure FOXM1 protein levels in 11 human myeloma cell lines (HMCLs) and then chose the two lines expressing the largest amount of the transcription factor, OPM2 and Delta47, for gene editing using CRISPR-Cas9. In both cases, two independent FOXM1-deficient daughter lines, designated KO-1 and KO-2, were generated. They contained 2 different 10-bp deletions at the target site of their respective guide RNA in case of OPM2 and a 10-bp deletion and 1-bp insertion in case of Delta47. Western analysis confirmed the lack of FOXM1 in all knockout clones. FOXM1-deficient myeloma cells proliferated more slowly than their parental counterparts containing normal levels of FOXM1. Moreover, we added back FOXM1 to FOXM1-KO cells by transfection of a constitutively expressed FOXM1c cDNA gene. The reconstituted OPM2 and Delta47 cells, designated FOXM1 KO-R contained high amounts of FOXM1 protein. Here, we used these cell lines to investigate the role of FOXM1 in regulating the gene expression in multiple myeloma.

2021-07-14 | GSE180018 | GEO

Determination of the Forkhead box A2 (FOXA2) Cistrome in the Human Endometrium

Project description:Determination of the Forkhead box A2 (FOXA2) Cistrome in the Human Endometrium

| PRJNA488467 | ENA

Fetal brain elicits sexually conflicting transcriptional response to the deficiency of uterine Forkhead Box A2 (Foxa2) in mice

Project description:RNA-seq identified different gene sets relating to biological functions such as aging, longevity, and nutrient sensing and signaling that were regulated in a sex-biased manner between the placenta and fetal brain. Conditional knockout of the transcription factor Forkhead Box A2 (Foxa2) in the uterus elicited sexual conflicting expression of those genes between the placenta and fetal brain.

2021-10-06 | GSE157555 | GEO

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