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Transcriptome comparison of the Streptococcus pneumoniae D39 ∆rgg144to D39 wild type grown in Mannose

ABSTRACT: Transcriptome comparison of the Streptococcus pneumoniae D39 ∆rgg144to D39 wild type grown in Mannose

PROVIDER: PRJNA445468 | ENA |

REPOSITORIES: ENA

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Transcriptome comparison of the Streptococcus pneumoniae D39 ∆rgg939 to D39 wild type grown in Mannose

Project description:Transcriptome comparison of the Streptococcus pneumoniae D39 ∆rgg939 to D39 wild type grown in Mannose

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Streptococcus pneumoniae D39 wild-type grown in CDM+10 mM arginine compared to D39 wild type grown in CDM + 0.05 mM arginine

Project description:Comparison of Streptococcus pneumoniae D39 wild-type grown in CDM+10 mM arginine compared to D39 wild type grown in CDM + 0.05 mM arginine to define the genome-wide transcriptional response to arginine. Details described in Kloosterman TG and Kuipers OP. ArgR1 and AhrC Mediate Arginine-Dependent Regulation of Arginine Acquisition- and Virulence Genes in the Human Pathogen Streptococcus pneumoniae. JBC 2011

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Transcriptome comparison of the Streptococcus pneumoniae D39 ∆rgg144to D39 wild type grown in Mannose

Project description:Microbes communicate with each other by using quorum sensing (QS) systems and modulate their collective ‘behavior’ for in-host colonization and virulence, biofilm formation, and environmental adaptation. The recent increase in genome data availability reveals the presence of several putative QS sensing circuits in microbial pathogens, but many of these have not been functionally characterized yet, despite their possible utility as drug targets. To increase the repertoire of functionally characterized QS systems in bacteria, we studied Rgg144/Shp144 and Rgg939/Shp939, two putative QS systems in the important human pathogen Streptococcus pneumoniae. We find that both of these QS circuits are induced by short hydrophobic peptides (Shp) upon sensing sugars found in the respiratory tract, such as galactose and mannose. Microarray analyses using cultures grown on mannose and galactose revealed that the expression of a large number of genes is controlled by these QS systems, especially those encoding for essential physiological functions and virulence-related genes such as the capsular locus. Moreover, the array data revealed evidence for cross-talk between these systems. Finally, these Rgg systems play a key role in colonization and virulence, as deletion mutants of these QS systems are attenuated in the mouse models of colonization and pneumonia.

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Transcriptome comparison of the Streptococcus pneumoniae D39 ∆rgg939 to D39 wild type grown in Mannose

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Transcriptome comparison of the Streptococcus pneumoniae D39 wild-type treated with 1mM to with 0mM H2O2

Project description:Transcriptome comparison of the Streptococcus pneumoniae D39 wild-type grown in THY medium till OD620=0.25 and then treated with or without 1mM H2O2 for 40mins.

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Transcriptome response of the Streptococcus pneumoniae D39 wild-type to Naicin

Project description:Transcriptome Comparison of the Streptococcus pneumoniae D39 wild-type grown in CDM with 0 mM to 10mM Niacin

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Transcriptome response of the Streptococcus pneumoniae D39 wild-type to Aspirin

Project description:Transcriptome Comparison of the Streptococcus pneumoniae D39 wild-type grown in CDM with 0 mM to 5mM Aspirin

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Transcriptome response of the Streptococcus pneumoniae D39 wild-type to cysteine

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Project description:We explored the regulatory mechanism of Leloir pathway genes in Streptococcus pneumoniae D39. Here, we demonstrate that the expression of galKT is galactose dependent. By microarray analysis and quantitative RT-PCR, we further show the role of the transcriptional regulator GalR, present upstream of galKT, as a transcriptional activator of galKT in the presence of galactose. Moreover, we predict a 19-bp regulatory site (5'-GATAGTTTAGTAAAATTTT-3' ) for the transcriptional regulator GalR in the promoter region of galK, which is also highly conserved in other streptococci. Growth comparison of Î galK with the D39 wildtype strain grown in the presence of galactose shows that galK is required for the proper growth of S. pneumoniae on galactose. Comparison of the Streptococcus pneumoniae D39 galR mutant compared to D39 wild type in M17 medium+ 0.5% (w/v) galactose (GalM17). One condition design comparison of two strains including a dye swap.

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