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Microarray expression profile and functional analysis of circular RNAs in cervical cancer

ABSTRACT: Microarray expression profile and functional analysis of circular RNAs in cervical cancer

PROVIDER: PRJNA453690 | ENA |

REPOSITORIES: ENA

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Microarray expression profile of circular RNAs in cervical cancer

Project description:Microarray expression profile of circular RNAs in cervical cancer

| PRJNA614955 | ENA

Microarray expression profile and functional analysis of circular RNAs in cervical cancer

Project description:Five human cervical cancer cell lines (HeLa, CaSki, SiHa, C-33A, SW756) and one human normal cervical epithelial cell line HcerEpic were included in the study. Microarray based circRNA expression profiles were acquired using the Arraystar Human circRNA Array (8x15K, Arraystar). We identified circRNAs differentially expressed in human cervical cancer cell lines compared to human normal cervical epithelial HcerEpic cells (control).

2018-04-27 | GSE113696 | GEO

Circular RNA profile of human cervical squamous cell carcinoma

Project description:Circular RNAs (circRNAs) represent a widespread class of non-coding RNAs, which drew little attention in the past. Recently, limited data showed their promising future to act as biomarkers in human cancer, but the characteristics and functions remain largely unknown in human cervical cancer. In this study, we demonstrated the expression profile of circRNAs in cervical squamous cell carcinoma(SCC) patients with circRNA microarray, and identified a large number of circRNAs possibly expressed in SCC.

2017-08-16 | GSE102686 | GEO

Microarray expression profile of circular RNAs in cervical cancer

Project description:Human immortal cervical cell line H8, human cervical cancer cell line SiHa and SiHa transfected with Wnt11-overexpression vector were included in the study. We identified circRNAs differentially expressed between H8 and SiHa or between SiHa and SiHa transfected with OV-Wnt11.

2020-03-25 | GSE147483 | GEO

Circular RNAs are super abundant in cervical tumor and plasma detected by high throughput microarray [standard_RNA_circRNA]

Project description:Circular RNAs (circRNAs) are a new class of endogenous and regulatory non-coding RNAs, but their expressions in tumor and plasma are largely unknown. Here, our study firstly suggested that microarray should be more efficient than RNA sequencing for circRNA profiling. Then, we detected ~80,000 circRNAs expressed in cervical tumors and matched normal tissues by microarray, and ~23,000 of them are differently expressed. The numbers of up- and down-regulated circRNAs during tumorigenesis are almost equal. In addition, we discovered that the expression of different circRNA isoforms from the same linear RNA also different. Strikingly, as much as ~18,000 circRNAs could be robustly detected in plasmas, and ~8,000 circRNAs show different expression after surgery of tumor removal. Altogether, taking advantage of the huge number of circRNAs detected in tumor and plasma, we provide strong evidence for circRNA expression, regulation and potential clinical application as non-invasive biomarkers.

2018-03-01 | GSE90740 | GEO

Circular RNAs are super abundant in cervical tumor and plasma detected by high throughput microarray [Plasma_circRNA]

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Circular RNAs are super abundant in cervical tumor and plasma detected by high throughput microarray [cervical_cancer_mRNA]

2018-03-01 | GSE90738 | GEO

Circular RNAs are super abundant in cervical tumor and plasma detected by high throughput microarray [cervical_cancer_circRNA]

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Microarray expression profile analysis of circular RNAs in human pancreatic ductal adenocarcinoma

Project description:To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC compared with normal samples, and provided potential targets for future treatment of PDAC and novel insights into PDAC biology. Analyze circular RNA expression in pancreatic ductal adenocarcinoma (PDAC) by microarray platform.

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