Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Anti-fatigure properties of Sasa quelpaertensis leaf extracts in mice

ABSTRACT: Anti-fatigure properties of Sasa quelpaertensis leaf extracts in mice

PROVIDER: PRJNA453928 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Anti-fatigure properties of Sasa quelpaertensis leaf extracts in mice

Project description:The study aimed the effects of Sasa quelpaertensis leaf hot water extract (SQH) on anti-fatigue function and the global gene expression pattern in muscle tissue. When rat skeletal muscle cells were cultured in hypoxic condition, the levels of lactate and lactate dehydrogenase (LDH) was increased approximately more than 2-fold, but SQH decreased effectively these levels. Thus, we assessed the exercise and fatigue recovery function using several physical biomarkers such as glycogen, lactate and so on in high intensity exercise mice. The mice were divided into three groups; Normal Control (NC), Exercise Control (EC), and Exercise SQH (ES) by oral administered at 50mg/kg/day for 7 days. After excessive swimming,the ES group showed increases serum glucose and decrease serum lactate than EC group. Lactate content in muscle was lower ES group than EC group. Glycogen contents in muscle and liver were higher ES group than EC group. And, SQH administration increased the expression of phospho-Acetyl-CoA (p-ACC), and reduced the expression of phospho-AMP-activated protein kinase (p-AMPK) and GLUT4 in in-vivo model. Also, genome wide expression profiles of tissue were determined by RNA sequencing. SQH up-regulates and down-regulates several genes associated with fatigue. In conclusion, this study suggested that SQH are effective for anti-fatigue agent.

2021-04-24 | GSE113759 | GEO

Effects of Morus alba L. (Mulberry) Leaf Extract in Hypercholesterolemic Mice on Suppression of Cholesterol Synthesis

2016-01-01 | GSE65839 | GEO

Effects of Morus alba L. (Mulberry) Leaf Extract in Hypercholesterolemic Mice on Suppression of Cholesterol Synthesis

Project description:To investigate effects of intake of mulberry leaf extracts on hypercholesterolemia, we performed gene expression profiling on rat liver by microarray analysis. Microarray analysis revealed that mulberry leaf extracts up-regulated the gene expression involved in suppression of cholesterol synthesis and stimulation of innate-adaptive Immunity. Mice were fed a high-cholesterol diet without/with orally administration of mulberry leaf extracts for 4 weeks. Livers were taken for RNA extraction and hybridization on Agilent microarrays.

2016-07-03 | E-GEOD-65839 | biostudies-arrayexpress

Identification of the pharmacological effects of Chrysanthemum morifolium Ramat leaves extracts on high-fat diet induced obese mice through lipid profiling

Project description:We investigated anti-obesity mechanism of Chrysanthemum morifolium Ramat leaves extracts on high-fat diet induced obese mice using lipid profiling and RNA-seq transcriptomic profling.

2020-11-16 | GSE124777 | GEO

CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice

Project description:CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice

| PRJNA542382 | ENA

Small RNA-seq from FPLC-fractionated leaf and flower crude extracts

Project description:Small RNA-seq from FPLC-fractionated leaf and flower crude extracts

| PRJNA540255 | ENA

The effects of kiwifruit extracts on colonic gene and protein expression levels in interleukin 10 gene-deficient mice.

Project description:Inflammatory Bowel Disease (IBD) is a term describing a collection of conditions characterised by chronic inflammatory disorder of the gastrointestinal tract involving an inappropriate immune response to commensal microorganisms in a genetically susceptible host. Four kiwifruit extracts, aqueous and ethyl acetate extracts of gold kiwifruit (Actinidia chinensis) or green kiwifruit (A. deliciosa), have previously demonstrated anti-inflammatory activity using in vitro models of IBD. This study examined whether these kiwifruit extracts had immune modulating effects in vivo against inflammatory processes known to be increased in patients with IBD. KFEs were used as a dietary intervention in Il10-/- mice (an in vivo model of IBD) and the C57BL/6J background strain in a 3 x 2 factorial design. While all Il10-/- mice developed significant colonic inflammation compared to the C57BL/6J mice, this was not affected by the inclusion of KFE in the diet. Whole genome gene and protein expression level profiling indicated that KFEs influenced immune signalling pathways and metabolic processes within the colonic tissue; however, the effects were subtle. In particular, adaptive immune pathways were reduced by three out of four kiwifruit extracts, with greater reduction seen in the C57BL/6J mice. This suggests that while immune-modulating activity was present in vivo, KFEs did not reduce inflammatory processes relevant to IBD. SUBMITTER_CITATION: Edmunds, Shelley Jane. The effects of kiwifruit extracts on gene and protein expression in in vitro and in vivo mouse models of inflammatory bowel disease. Diss. University of Auckland, New Zealand, 2010. http://hdl.handle.net/2292/6623

2011-03-05 | GSE27684 | GEO

Identification of the anti-mycobacterial functional properties of piperidinol derivatives

Project description:Identification of the anti-mycobacterial functional properties of piperidinol derivatives

| PRJEB15140 | ENA

Apoptotic cells actively release metabolite messanger with anti-inflammatory properties

Project description:Apoptotic cells actively release metabolite messanger with anti-inflammatory properties

| PRJNA545309 | ENA

Anti-inflammatory properties of low dose epirubicin on human macrophages

Project description:Anti-inflammatory properties of low dose epirubicin on human macrophages

| PRJNA563607 | ENA