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7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

ABSTRACT: 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

PROVIDER: PRJNA454904 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7109576_1.fastq.gz	Fastqsanger.gz
	SRR7109576_2.fastq.gz	Fastqsanger.gz
	SRR7109577_1.fastq.gz	Fastqsanger.gz
	SRR7109577_2.fastq.gz	Fastqsanger.gz
	SRR7109578_1.fastq.gz	Fastqsanger.gz

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Expression data from 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

Project description:We found genetic deletion of IKKβ in mdx cardiomyocytes improved cardiac function and normalized calcium transients. We used microarrays to profile gene expression in hearts of mdx mice with intact IKKβ signaling and hearts of mdx mice with IKKβ-deficient cardiomyocytes to identify genes differentially regulated by NF-[kappa]B. signaling in dystrophic hearts.

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ChIP-seq data for H3K27 acetylation from 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

Project description:We found genetic deletion of IKKβ in mdx cardiomyocytes improved cardiac function and normalized calcium transients, and that differential gene expression favored a repressive function for NF-[kappa]B in these mice. We suspected that NF-[kappa]B was conferring a more restrictive chromatin conformation in a subset of genes. ChIP-seq was performed for H3K27 acetylation to show this repressive function for NF-[kappa]B was a global effect and to identify specific genes with more permissive chromatin conformation in hearts of mdx mice with IKKβ-deficient cardiomyocytes compared to mdx mice with intact IKKβ signaling.

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Expression data from 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

Project description:Expression data from 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

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ChIP-seq data for H3K27 acetylation from 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

Project description:ChIP-seq data for H3K27 acetylation from 7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

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Expression data from adult (9 month-old) and young (4 month-old) hearts from C57BL/6J mice

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7-month-old mdx mouse hearts wild-type and deficient for cardiomyocyte-specific IKKβ

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-06-13 | GSE114026 | GEO

Expression data from adult (9 month-old) and young (4 month-old) hearts from GRK2 heterozygous C57BL/6J mice.

Project description:G protein-coupled receptor kinase 2 (GRK2) has emerged as a key regulator of cardiac function and myocardial structure. Cardiac GRK2 is increased in heart failure and ischemia in humans, whereas genetic inhibition of GRK2 is cardioprotective in animal models of these pathologies. However, the mechanistic basis underlying these effects are not fully understood. We have used adult GRK2 hemizygous mice (GRK2+/-) as a model to assess the effects of a sustained systemic inhibition of GRK2 in heart tissue with age. We used microarrays to determine the global programme of gene expression underlying cardioprotection in GRK2 hemizygous mice with age. 9 month-old and 4 month-old mice hearts were collected for RNA extraction and hybridization on Affymetrix microarrays.

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