Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ATAC-seq]

ABSTRACT: H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ATAC-seq]

PROVIDER: PRJNA471719 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7172402_1.fastq.gz	Fastqsanger.gz
	SRR7172402_2.fastq.gz	Fastqsanger.gz
	SRR7172403_1.fastq.gz	Fastqsanger.gz
	SRR7172403_2.fastq.gz	Fastqsanger.gz
	SRR7172404_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 8

Similar Datasets

H3.3 phosphorylation promotes enhancer acetylation and lineage specification

Project description:H3.3 phosphorylation promotes enhancer acetylation and lineage specification

| PRJNA471713 | ENA

H3.3 phosphorylation promotes enhancer acetylation and lineage specification [RNA-seq]

Project description:H3.3 phosphorylation promotes high levels of histone acetylation in mouse embryonic stem cells, which are central to the initiation of new transcription during lineage specification.

2019-06-07 | GSE114549 | GEO

H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ChIP-seq]

2019-06-07 | GSE114548 | GEO

H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ATAC-seq]

2019-06-07 | GSE114547 | GEO

H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ATAC-seq]

Project description:H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ATAC-seq]

| PRJNA471719 | ENA

H3.3 phosphorylation promotes enhancer acetylation and lineage specification [RNA-seq]

Project description:H3.3 phosphorylation promotes enhancer acetylation and lineage specification [RNA-seq]

| PRJNA471726 | ENA

H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ChIP-seq]

Project description:H3.3 phosphorylation promotes enhancer acetylation and lineage specification [ChIP-seq]

| PRJNA471722 | ENA

H3.3 phosphorylation promotes enhancer acetylation and lineage specification

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-06-07 | GSE114551 | GEO

Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation.

Project description:The histone variant H3.3 is enriched at enhancers and active genes, as well as repeat regions such as telomeres and retroelements, in mouse embryonic stem cells (mESCs)1-3. Although recent studies demonstrate a role for H3.3 and its chaperones in establishing heterochromatin at repeat regions4-8, the function of H3.3 in transcription regulation has been less clear9-16. Here, we find that H3.3-specific phosphorylation17-19 stimulates activity of the acetyltransferase p300 in trans, suggesting that H3.3 acts as a nucleosomal cofactor for p300. Depletion of H3.3 from mESCs reduces acetylation on histone H3 at lysine 27 (H3K27ac) at enhancers. Compared with wild-type cells, those lacking H3.3 demonstrate reduced capacity to acetylate enhancers that are activated upon differentiation, along with reduced ability to reprogram cell fate. Our study demonstrates that a single amino acid in a histone variant can integrate signaling information and impact genome regulation globally, which may help to better understand how mutations in these proteins contribute to human cancers20,21.

| S-EPMC6598431 | biostudies-literature

Protein kinase C coordinates histone H3 phosphorylation and acetylation

Project description:The re-assembly of chromatin following DNA replication is a critical event in the maintenance of genome integrity. Histone H3 acetylation at K56 and phosphorylation at T45 are two important chromatin modifications that accompany chromatin assembly. Here we report a microarray expression study of the protein kinase Pkc1, histone acetyl transferase Rtt109 and histone H3 in Saccharomyces cerevisiae under conditions of replicative stress.

2015-12-04 | E-MTAB-3359 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data