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Identification of cell type specfici markers for type I and type II Hair cells in the mouse utricle using single cell RNAseq

ABSTRACT: Identification of cell type specfici markers for type I and type II Hair cells in the mouse utricle using single cell RNAseq

PROVIDER: PRJNA476552 | ENA |

REPOSITORIES: ENA

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Cell-type identity of the avian utricle

Project description:The avian utricle, a vestibular organ of the inner ear, displays turnover of sensory hair cells throughout life. This is in sharp contrast to the mammalian utricle, which shows limited regenerative capacity. Here, we use single-cell RNA-sequencing to identify distinct marker genes for the different sensory hair cell subtypes of the chicken utricle, which we validated in situ . We provide markers for spatially distinct supporting cell populations, and identified two transitional cell populations of dedifferentiating supporting cells and developing hair cells. Trajectory reconstruction resulted in an inventory of gene expression dynamics of natural hair cell generation in the avian utricle.

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Identification of cell type specfici markers for type I and type II Hair cells in the mouse utricle using single cell RNAseq

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