Project description:It has been demonstrated that parvovirus infection causing cytotoxicity and immune activation effect in many virus-induced cell lines, however, the underlying mechanisms are not fully understood. To investigate the gene expression signature of host cell after CPV-2 infection, we performed transcriptome profiling of MDCK after persistent infection of CPV-2a using microarray analysis. Uninfected MDCK cells act as negative control. The data show the genes regulated by CPV-2 infection..

2016-12-01 | GSE72397 | GEO

Porcine parvovirus 1 strain:CH/HN-3/2021 | isolate:Lung tissue | breed:swine

Project description:Porcine parvovirus 1 strain:CH/HN-3/2021 | isolate:Aborted fetus | breed:Porcine | Genome sequencing and assembly

| PRJNA745036 | ENA

Detection and characterization of microRNA expression profiling and its target genes in response to canine parvovirus in Crandell Reese Feline Kidney cells

Project description:We utilized high-throughput small RNA-seq technology to investigate the altered miRNA profiling in miRNA libraries from uninfected (Control) and canine parvovirus type 2c (CPV-2c) infected Crandell Reese Feline Kidney (CRFK) cells. We identified five of known miRNAs (miR-222-5p, miR-365-2-5p, miR-1247-3p, miR-322-5p, and miR-361-3p) and 3 novel miRNAs (Novel 137, Novel 141, and Novel 102) by small RNA-seq with differentially expressed genes (DEGs) in the miRNA repertoire of CPV-infected cells over control. We further predicted the potential target genes of aforementioned miRNAs using sequence homology algorithms. Notably, the targets of miR-1247-3p exhibited a potential function associated with cellular defense and humoral response to CPV. We discovered 229 putative targets from a total of 38 enriched GO terms. We next constructed GO biological process network composed of 28 target genes of miR-1247-3p, of which, some genes, namely BCL6, DLL1, GATA3, IL6, LEF1, LFNG, and WNT1 were among the genes with obviously intersected in multiple GO terms. The miRNA-1247-3 and its cognate target genes suggested the great potential as novel therapeutic targets or diagnostic biomarkers of CPV or other related viruses.

2019-08-20 | GSE135948 | GEO

Human parvovirus

Project description:Human parvovirus viral integrations into human cell types

| PRJNA208398 | ENA

Canine

Project description:Canine

| PRJNA687522 | ENA

Transcription profiling of U937 promonocytic cell line vs U937 promonocytic cell line, infected with wiltdype parvovirus H1 (H1_wt)

Project description:1) Ctrl Probe: U937 promonocytic cell line. 2) U937 promonocytic cell line, infected with wiltyp parvovirus H1 (H1_wt).

2013-01-30 | E-RZPD-4 | biostudies-arrayexpress

An atypical parvovirus driving chronic tubulointerstitial nephropathy and kidney fibrosis

Project description:We have performed RNA sequencing on kidneys from inclusion body nephropathy-affected mice and compared the data to healthy, uninfected controls. Using a metagenomics approach, we report the identification of the disease causing agent as an atypical virus, mouse kidney parvovirus (MKPV), belonging to a divergent genus of the Parvoviridae. The RNA sequencing also enabled us to assess the host response to MKPV-infection.

2018-07-27 | GSE117710 | GEO

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