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Next Generation Sequencing Facilitates Quantitative Analysis of ischemic postconditioning (IPO) to attenuate hepatic ischemia-reperfusion injury in mice

ABSTRACT: Next Generation Sequencing Facilitates Quantitative Analysis of ischemic postconditioning (IPO) to attenuate hepatic ischemia-reperfusion injury in mice

PROVIDER: PRJNA481000 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7518410_1.fastq.gz	Fastqsanger.gz
	SRR7518410_2.fastq.gz	Fastqsanger.gz
	SRR7518411_1.fastq.gz	Fastqsanger.gz
	SRR7518411_2.fastq.gz	Fastqsanger.gz
	SRR7518412_1.fastq.gz	Fastqsanger.gz

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Ischemic Pre- and Post Conditioning has pronounced effects on Gene Expression Profiles in the Rat Liver after Ischemia/Reperfusion

Project description:Ischemia/reperfusion injuries is a known complication to hepatic surgery. Ischemic pre- (IPC) and postconditioning (IPO) protects the liver against ischemia/reperfusion-injuries. Expression profiling were performed on liver biopsies seeking to identify molecular mediators of the protective properties. 48 rats were divided into 5 groups; sham (n=8), IRI (n=10), IPC (n=10), IPO (n=10) and IPC+IPO (n=10). All rats except sham rats were subjected to 30 min of total liver ischemia and 30 min of reperfusion before liver biopsies were sampled. In the IPC group, liver ischemia was preceded by 10 min of hepatic ischemia, followed by 10 min of reperfusion. IPO were performed by three cycles of 30 sec of reperfusion and 30 sec of ischemia, applied immediately after the 30 min of total liver ischemia. In the IPC+IPO group the two interventions were combined.

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Project description:circRNAs microarray analysis of ischemic postconditioning (IPO) to attenuate hepatic ischemia-reperfusion injury in mice

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circRNAs microarray analysis of ischemic postconditioning (IPO) to attenuate hepatic ischemia-reperfusion injury in mice

Project description:this is the first study to investigate circRNA expression profiling in regard to hepatic I/R and IPO by microarray analysis. Our results may provide an experimental basis for elucidating the underlying mechanism of IPO and reveal candidate biomarkers with which to assess hepatic I/R injury

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Next Generation Sequencing Facilitates Quantitative Analysis of ischemic postconditioning (IPO) to attenuate hepatic ischemia-reperfusion injury in mice

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