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IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

ABSTRACT: IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

PROVIDER: PRJNA485698 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7687940.fastq.gz	Fastqsanger.gz
	SRR7687950.fastq.gz	Fastqsanger.gz
	SRR7687941.fastq.gz	Fastqsanger.gz
	SRR7687951.fastq.gz	Fastqsanger.gz
	SRR7687942.fastq.gz	Fastqsanger.gz

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IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection

| PRJNA473488 | ENA

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

Project description:Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in mouse DCs in response to virus infection. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.

2018-12-14 | GSE114991 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

2018-12-14 | GSE114992 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (BMM_RNA-Seq)

2018-12-14 | GSE118452 | GEO

IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (RNA-Seq)

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IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

Project description:IRF5 regulates unique subset of genes in mouse dendritic cells during West Nile virus infection (ChIP-Seq)

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IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.

Project description:Pathogen recognition receptor (PRR) signaling is critical for triggering innate immune activation and the expression of immune response genes, including genes that impart restriction against virus replication. RIG-I-like receptors and TLRs are PRRs that signal immune activation and drive the expression of antiviral genes and the production of type I IFN leading to induction of IFN-stimulated genes, in part through the interferon regulatory factor (IRF) family of transcription factors. Previous studies with West Nile virus (WNV) showed that IRF3 and IRF7 regulate IFN expression in fibroblasts and neurons, whereas macrophages and dendritic cells (DCs) retained the ability to induce IFN-? in the absence of IRF3 and IRF7 in a manner implicating IRF5 in PRR signaling actions. Here we assessed the contribution of IRF5 to immune gene induction in response to WNV infection in DCs. We examined IRF5-dependent gene expression and found that loss of IRF5 in mice resulted in modest and subtle changes in the expression of WNV-regulated genes. Anti-IRF5 chromatin immunoprecipitation with next-generation sequencing of genomic DNA coupled with mRNA analysis revealed unique IRF5 binding motifs within the mouse genome that are distinct from the canonical IRF binding motif and that link with IRF5-target gene expression. Using integrative bioinformatics analyses, we identified new IRF5 primary target genes in DCs in response to virus infection. This study provides novel insights into the distinct and unique innate immune and immune gene regulatory program directed by IRF5.

| S-EPMC6355374 | biostudies-literature

West Nile virus

Project description:West Nile virus overview

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scRNA-seq of peripheral blood from West Nile Virus-infected patients

Project description:We profile the peripheral blood of patients infected with West Nile Virus with divergent disease-trajectories (West Nile Encephalitis, West Nile Fever, and asymptomatic) during relatively acute infection and at a convalescent timepoint (~90-days later) using single-cell RNA sequencing in an effort to uncover determinants of disease progression and flesh out the landscape of infection. In the blood of the infected patients, stratified cell-states involved in acute viral infection resolve into more homogenous states at the follow-up blood draws, A dramatic shared transcriptional shift between the primary blood-draws during acute infection and the 90-day follow-ups in all observed compartments allows us to highlight multiple cell-type and cell-state-specific patterns of gene expression.

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Project description:Purpose of this experiment was to further understand how innate immune defenses impact host response and West Nile virus tissue tropism. This study examined host-transcriptional response to West Nile virus in permissive and nonpermissive tissues using wildtype mice and mice with genetically altered interferon signaling pathways.

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