Ontology highlight
ABSTRACT:
PROVIDER: PRJNA509256 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:This dataset is provided in support of the identification of a collagen-degrading enzyme secreted by the fungus P. destructans. P. destructans is responsible for the disease white nose syndrome, which has infected and killed millions of North American bats. Our manuscript, titled "Destructin-1 is a Collagen-Degrading Endopeptidase Secreted by P. destructans, the Causative Agent of White-Nose Syndrome", is under review, and the data set will be released upon acceptance.
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Project description:Fungus Causing White-Nose Syndrome in Bats Accumulates Genetic Variability in North America With No Sign of Recombination
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Project description:Vampire bats and snakes have taken thermosensation to the extreme by developing specialized systems for detecting infrared radiation. As such, these creatures provide a window into the molecular and genetic mechanisms underlying evolutionary tuning of thermoreceptors in a species or cell type specific manner. In each case, robust thermal sensitivity likely reflects specialized anatomical features of infrared sensing pit organs, as well as intrinsic heat sensitivity of trigeminal nerve fibers that innervate these structures. Here we show that vampire bats use a molecular strategy involving alternative splicing of the TRPV1 gene to generate a channel specifically within trigeminal ganglia that has a reduced thermal activation threshold. Selective expression of splicing factors in trigeminal, but not dorsal root ganglia, together with unique organization of the vampire bat TRPV1 gene underlies this mechanism of sensory adaptation. Comparative genomic analysis of the TRPV1 locus supports phylogenetic relationships within the proposed Pegasoferae clade of mammals. Gene expression measurements implicate a TRPV1 splice isoform as the heat-sensitive channel in vampire bats
2011-08-04 | E-GEOD-28243 | biostudies-arrayexpress
Project description:This data is in support of a study entitled "Characterization of PdCP1, a Serine Carboxypeptidase from P. destructans, the Causal Agent of White-nose Syndrome" by Beekman, C. et al. which is submitted and under review. Data will be released upon acceptance of the publication.
2018-04-30 | MSV000082319 | MassIVE