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Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq 2]

ABSTRACT: Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq 2]

PROVIDER: PRJNA513981 | ENA |

REPOSITORIES: ENA

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Insulin receptor associates with promoters genome-wide and regulates gene expression

Project description:Insulin receptor associates with promoters genome-wide and regulates gene expression

| PRJNA419799 | ENA

Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq]

Project description:Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq]

| PRJNA419800 | ENA

Insulin receptor associates with promoters genome-wide and regulates gene expression [ChIP-seq]

Project description:Insulin receptor associates with promoters genome-wide and regulates gene expression [ChIP-seq]

| PRJNA419801 | ENA

Insulin receptor associates with promoters genome-wide and regulates gene expression [ChIP-seq]

Project description:ChIP-seq analysis demonstrates an association of insulin receptor (IR) and RNA polymerase II on chromatin, with striking enrichment at gene promoters.

2019-04-04 | GSE107335 | GEO

Insulin receptor associates with promoters genome-wide and regulates gene expression [RNA-seq]

Project description:RNA-seq analysis identifies transcripts regulated by insulin treatment.

2019-04-04 | GSE107334 | GEO

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition

Project description:Global energy balance in mammals is controlled by the actions of circulating hormones that coordinate fuel production and utilization in metabolically active tissues. Bone-derived osteocalcin, in its undercarboxylated, hormonal form, regulates fat deposition and is a potent insulin secretagogue. Here, we show that insulin receptor (IR) signaling in osteoblasts controls osteoblast development and osteocalcin expression by suppressing the Runx2 inhibitor Twist-2. Mice lacking IR in osteoblasts have low circulating undercarboxylated osteocalcin and reduced bone acquisition due to decreased bone formation and deficient numbers of osteoblasts. With age, these mice develop marked peripheral adiposity and hyperglycemia accompanied by severe glucose intolerance and insulin resistance. The metabolic abnormalities in these mice are improved by infusion of exogenous under-carboxylated osteocalcin. These results indicate the existence of a bone-pancreas endocrine loop through which insulin signaling in the osteoblast ensures osteoblast differentiation and stimulates osteocalcin production, which in turn regulates insulin sensitivity and pancreatic insulin secretion to control glucose homeostasis. We used microarrays to detail the global gene expression changes in response to insulin acting through insulin receptor in osteoblasts and identified distinct genes specifically involved in bone remodeling process. 4 groups and 3 time points (0h as a control, 6h, 12h, and 24h)

2010-05-27 | E-GEOD-21710 | biostudies-arrayexpress

Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression.

Project description:Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in prevalent chronic diseases. IR binds insulin at the cell surface and transduces rapid signaling via cytoplasmic kinases. However, mechanisms mediating long-term effects of insulin remain unclear. Here, we show that IR associates with RNA polymerase II in the nucleus, with striking enrichment at promoters genome-wide. The target genes were highly enriched for insulin-related functions including lipid metabolism and protein synthesis and diseases including diabetes, neurodegeneration, and cancer. IR chromatin binding was increased by insulin and impaired in an insulin-resistant disease model. Promoter binding by IR was mediated by coregulator host cell factor-1 (HCF-1) and transcription factors, revealing an HCF-1-dependent pathway for gene regulation by insulin. These results show that IR interacts with transcriptional machinery at promoters and identify a pathway regulating genes linked to insulin's effects in physiology and disease.

| S-EPMC6478446 | biostudies-literature

Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition

2010-05-07 | GSE21710 | GEO

Insulin receptor associates with promoters genome-wide and regulates gene expression

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-04-04 | GSE107336 | GEO

A signaling hub of insulin receptor dystrophin glycoprotein complex and plakoglobin regulates muscle size

Project description:Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activity requires association with the fundamental structural module in muscle, the dystrophin glycoprotein complex (DGC), and the desmosomal component plakoglobin (g-catenin). The integrity of this high-molecular-mass assembly renders skeletal muscle susceptibility to insulin because DGC-insulin receptor dissociation by plakoglobin downregulation reduced insulin signaling and caused atrophy. Furthermore, low insulin receptor activity in muscles from transgenic or fasted mice decreased plakoglobin-DGC-insulin receptor content on the plasma membrane, but not when plakoglobin was overexpressed. By masking b-dystroglycan LIR domains, plakoglobin prevents autophagic clearance of plakoglobin-DGC-insulin receptor co-assemblies and maintains their function. Our findings establish DGC as a signaling hub, and provide a possible mechanism for the insulin resistance in Duchenne Muscular Dystrophy, and for the cardiomyopathies seen with plakoglobin mutations.

2020-03-19 | PXD016989 | Pride

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