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Identify signature genes associated with nanoparticle carrying IRF5 mRNA treatment in isolated peritoneal macrophages from ID8 cells-induced ovarian tumor mouse

ABSTRACT: Identify signature genes associated with nanoparticle carrying IRF5 mRNA treatment in isolated peritoneal macrophages from ID8 cells-induced ovarian tumor mouse

PROVIDER: PRJNA531507 | ENA |

REPOSITORIES: ENA

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Identify signature genes associated with nanoparticle carrying IRF5 mRNA treatment in isolated peritoneal macrophages from ID8 cells-induced ovarian tumor mouse

Project description:To identify signature genes associated with nanoparticles carrying IRF5 mRNA treatment on peritoneal macrophages, we analyzed 770 genes in 19 different pathways and processes across 7 different myeloid cell types.

2019-04-09 | GSE129498 | GEO

Identify signature genes associated with nanoparticle carrying IRF5 mRNA treatment in bone marrow derrived macrophages

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RNA-seq analysis of ID8 ovarian cancer cells after harvest from malignant ascites

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ID8 whole exome sequence

Project description:The data in this submission relate to whole exome sequencing from murine ovarian cancer cell line ID8. All sequencing was performed by Beckman Coulter Genomics, Grenoble, France in February 2013.

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Genome-wide maps of chromatin state of IRF5+/+ and IRF5-/- CD4+ mouse T cells

Project description:Genetic variants in IRF5 are associated with multiple immune-mediated diseases. IRF5 has been predominantly focused on for its regulation of myeloid-derived cells. We found that IRF5 contributes to CD4+ T cell outcomes and that it regulates early T cell receptor-initiated signaling and subsequently translocates to the nucleus where it binds to promoters of various genes regulated with T cell activation. We report the chromatin state of freshly isolated and activated IRF5+/+ and IRF5-/- CD4+ T cells in vitro. While there are minimal differential peaks between freshly isolated IRF5+/+ and IRF5-/- CD4+ T cells, once activated multiple differential peaks are observed between IRF5+/+ and IRF5-/- CD4+ T cells.

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