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Histone mark modifications in murine ovary after gestational exposure to chlordecone

ABSTRACT: Histone mark modifications in murine ovary after gestational exposure to chlordecone

PROVIDER: PRJNA533110 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8910496.fastq.gz	Fastqsanger.gz
	SRR8910497.fastq.gz	Fastqsanger.gz
	SRR8910498.fastq.gz	Fastqsanger.gz
	SRR8910499.fastq.gz	Fastqsanger.gz

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Histone mark modifications in murine ovary after gestational exposure to chlordecone

Project description:We hypothesized that gestational exposure to chlordecone can lead to alteration of murine ovary's epigenetic landscape. To test our hypothesis, we exposed mice to chlordecone during embryonic development and we analyzed F1 female progeny epigenetic mark H3K4me3 in ovaries. We performed ChIP using anti-H3K4me3 commercial antibody (Merck Millipore, 07-473). DNA-protein complexes were immunoprecipitated, eluted and then DNA were purified.

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Transgenerational effect of Chlordecone

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Project description:The environmental factors such as pesticides could affect the developmental processes and cause the phenotypic changes. Moreover, the changes could be transferred to a subsequent generation via gametes. In this project we studied whether the pesticide chlordecone could cause the developmental effects and cause the transgenerational inheritance in outbred mouse strain. Mice were treated during development at dose 100 µg/kg/day and the progeny of exposed mice were crossed for three generations. The testes of the third generations males were used for anti-H3K4me3 ChiP-seq analysis. We used two biological replicates for each condition.

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